Korrelation zwischen dem Spiegel des zirkulierenden vaskulären endothelialen Wachstumsfaktors und Krankheitsaktivität bei rheumatoider Arthritis: eine Metaanalyse

Translated title of the contribution: Correlation between circulating VEGF levels and disease activity in rheumatoid arthritis: a meta-analysis

Young Ho Lee, Sang Cheol Bae

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. Methods: We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the risk for RA. Results: In total, 13 studies including 2508 patients with RA and 2489 controls were included. Meta-analysis revealed that VEGF level was significantly higher in the RA than in the control group (standard mean difference [SMD] = 1.480, 95% confidence interval [CI] = 0.71–2.241, p = 1.4 × 10−4). Stratification by adjustment for age and gender revealed significantly higher VEGF levels for the adjustment and non-adjustment groups in the RA group (SMD = 1.360, 95% CI = 0.445–2.276, p = 0.004; SMD = 1.557, 95% CI = 0.252–2.861, p = 0.019, respectively). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating VEGF levels and disease activity in RA, and between circulating VEGF and C‑reactive protein levels. However, no association was found between RA and the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms. Conclusion: Our meta-analysis revealed significantly higher circulating VEGF levels in patients with RA and a positive correlation between VEGF levels and disease activity in RA, but no association between the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the development of RA.

Original languageGerman
Pages (from-to)1-9
Number of pages9
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2016 Nov 14

Fingerprint

Vascular Endothelial Growth Factor A
Meta-Analysis
Rheumatoid Arthritis
Confidence Intervals
Serum

Keywords

  • Level
  • Polymorphism
  • Rheumatoid arthritis
  • VEGF

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{48f1cf81b1eb4000b5c2f49353c86c0d,
title = "Korrelation zwischen dem Spiegel des zirkulierenden vaskul{\"a}ren endothelialen Wachstumsfaktors und Krankheitsaktivit{\"a}t bei rheumatoider Arthritis: eine Metaanalyse",
abstract = "Objective: To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. Methods: We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the risk for RA. Results: In total, 13 studies including 2508 patients with RA and 2489 controls were included. Meta-analysis revealed that VEGF level was significantly higher in the RA than in the control group (standard mean difference [SMD] = 1.480, 95{\%} confidence interval [CI] = 0.71–2.241, p = 1.4 × 10−4). Stratification by adjustment for age and gender revealed significantly higher VEGF levels for the adjustment and non-adjustment groups in the RA group (SMD = 1.360, 95{\%} CI = 0.445–2.276, p = 0.004; SMD = 1.557, 95{\%} CI = 0.252–2.861, p = 0.019, respectively). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating VEGF levels and disease activity in RA, and between circulating VEGF and C‑reactive protein levels. However, no association was found between RA and the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms. Conclusion: Our meta-analysis revealed significantly higher circulating VEGF levels in patients with RA and a positive correlation between VEGF levels and disease activity in RA, but no association between the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the development of RA.",
keywords = "Level, Polymorphism, Rheumatoid arthritis, VEGF",
author = "Lee, {Young Ho} and Bae, {Sang Cheol}",
year = "2016",
month = "11",
day = "14",
doi = "10.1007/s00393-016-0229-5",
language = "German",
pages = "1--9",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",

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TY - JOUR

T1 - Korrelation zwischen dem Spiegel des zirkulierenden vaskulären endothelialen Wachstumsfaktors und Krankheitsaktivität bei rheumatoider Arthritis

T2 - eine Metaanalyse

AU - Lee, Young Ho

AU - Bae, Sang Cheol

PY - 2016/11/14

Y1 - 2016/11/14

N2 - Objective: To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. Methods: We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the risk for RA. Results: In total, 13 studies including 2508 patients with RA and 2489 controls were included. Meta-analysis revealed that VEGF level was significantly higher in the RA than in the control group (standard mean difference [SMD] = 1.480, 95% confidence interval [CI] = 0.71–2.241, p = 1.4 × 10−4). Stratification by adjustment for age and gender revealed significantly higher VEGF levels for the adjustment and non-adjustment groups in the RA group (SMD = 1.360, 95% CI = 0.445–2.276, p = 0.004; SMD = 1.557, 95% CI = 0.252–2.861, p = 0.019, respectively). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating VEGF levels and disease activity in RA, and between circulating VEGF and C‑reactive protein levels. However, no association was found between RA and the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms. Conclusion: Our meta-analysis revealed significantly higher circulating VEGF levels in patients with RA and a positive correlation between VEGF levels and disease activity in RA, but no association between the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the development of RA.

AB - Objective: To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. Methods: We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the risk for RA. Results: In total, 13 studies including 2508 patients with RA and 2489 controls were included. Meta-analysis revealed that VEGF level was significantly higher in the RA than in the control group (standard mean difference [SMD] = 1.480, 95% confidence interval [CI] = 0.71–2.241, p = 1.4 × 10−4). Stratification by adjustment for age and gender revealed significantly higher VEGF levels for the adjustment and non-adjustment groups in the RA group (SMD = 1.360, 95% CI = 0.445–2.276, p = 0.004; SMD = 1.557, 95% CI = 0.252–2.861, p = 0.019, respectively). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating VEGF levels and disease activity in RA, and between circulating VEGF and C‑reactive protein levels. However, no association was found between RA and the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms. Conclusion: Our meta-analysis revealed significantly higher circulating VEGF levels in patients with RA and a positive correlation between VEGF levels and disease activity in RA, but no association between the VEGF −2578 A/C, −634 C/G, +936 T/C, and −1154 A/G polymorphisms and the development of RA.

KW - Level

KW - Polymorphism

KW - Rheumatoid arthritis

KW - VEGF

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