Correlation between ovarian reserve and incidence of ectopic pregnancy after in vitro fertilization and embryo transfer

Sung Woo Kim, Yong Jin Kim, Jung-Ho Shin, Hoon Kim, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi

Research output: Contribution to journalArticle

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Abstract

Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. Materials and Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p=0.012) analysis, DOR was associated with a higher risk of EP. Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalYonsei medical journal
Volume60
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Ectopic Pregnancy
Embryo Transfer
Fertilization in Vitro
Incidence
Ovulation Induction
High-Risk Pregnancy
Follicle Stimulating Hormone
Infertility
Ovarian Reserve
Odds Ratio
Hormones
Confidence Intervals
Oocyte Retrieval
Chorionic Gonadotropin
Pregnancy Outcome
Oocytes
Observational Studies
Pregnant Women
Embryonic Structures

Keywords

  • Anti-Müllerian hormone
  • Ectopic pregnancy
  • Follicle stimulating hormone
  • In vitro fertilization
  • Ovarian stimulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Correlation between ovarian reserve and incidence of ectopic pregnancy after in vitro fertilization and embryo transfer. / Kim, Sung Woo; Kim, Yong Jin; Shin, Jung-Ho; Kim, Hoon; Ku, Seung Yup; Suh, Chang Suk; Kim, Seok Hyun; Choi, Young Min.

In: Yonsei medical journal, Vol. 60, No. 3, 01.03.2019, p. 285-290.

Research output: Contribution to journalArticle

Kim, Sung Woo ; Kim, Yong Jin ; Shin, Jung-Ho ; Kim, Hoon ; Ku, Seung Yup ; Suh, Chang Suk ; Kim, Seok Hyun ; Choi, Young Min. / Correlation between ovarian reserve and incidence of ectopic pregnancy after in vitro fertilization and embryo transfer. In: Yonsei medical journal. 2019 ; Vol. 60, No. 3. pp. 285-290.
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abstract = "Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. Materials and Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-M{\"u}llerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7{\%} vs. 83.4{\%}, respectively) or chemical (14.7{\%} vs. 14.1{\%}, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7{\%} (8/75) vs. 2.5{\%} (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6, 95{\%} confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 {\%} CI 1.1–18.7, p=0.012) analysis, DOR was associated with a higher risk of EP. Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.",
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AU - Kim, Yong Jin

AU - Shin, Jung-Ho

AU - Kim, Hoon

AU - Ku, Seung Yup

AU - Suh, Chang Suk

AU - Kim, Seok Hyun

AU - Choi, Young Min

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N2 - Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. Materials and Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p=0.012) analysis, DOR was associated with a higher risk of EP. Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.

AB - Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. Materials and Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p=0.012) analysis, DOR was associated with a higher risk of EP. Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.

KW - Anti-Müllerian hormone

KW - Ectopic pregnancy

KW - Follicle stimulating hormone

KW - In vitro fertilization

KW - Ovarian stimulation

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