Correlation of coronary and cerebral atherosclerosis: Difference between extracranial and intracranial arteries

Hee Joon Bae, Byung Woo Yoon, Dong Wha Kang, Ja Seong Koo, Seung Hoon Lee, Ki Bong Kim, Juneyoung Lee, Jae Kyu Roh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalCerebrovascular Diseases
Volume21
Issue number1-2
DOIs
Publication statusPublished - 2006 Jan 1

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Intracranial Arteriosclerosis
Coronary Artery Disease
Arteries
Carotid Artery Diseases
Doppler Duplex Ultrasonography
Social Adjustment
Magnetic Resonance Angiography
Transient Ischemic Attack
Nonparametric Statistics
Hyperlipidemias
Coronary Angiography
Coronary Artery Bypass

Keywords

  • Carotid atherosclerosis
  • Coronary artery bypass
  • Coronary atherosclerosis
  • Intracranial atherosclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Bae, H. J., Yoon, B. W., Kang, D. W., Koo, J. S., Lee, S. H., Kim, K. B., ... Roh, J. K. (2006). Correlation of coronary and cerebral atherosclerosis: Difference between extracranial and intracranial arteries. Cerebrovascular Diseases, 21(1-2), 112-119. https://doi.org/10.1159/000090209

Correlation of coronary and cerebral atherosclerosis : Difference between extracranial and intracranial arteries. / Bae, Hee Joon; Yoon, Byung Woo; Kang, Dong Wha; Koo, Ja Seong; Lee, Seung Hoon; Kim, Ki Bong; Lee, Juneyoung; Roh, Jae Kyu.

In: Cerebrovascular Diseases, Vol. 21, No. 1-2, 01.01.2006, p. 112-119.

Research output: Contribution to journalArticle

Bae, Hee Joon ; Yoon, Byung Woo ; Kang, Dong Wha ; Koo, Ja Seong ; Lee, Seung Hoon ; Kim, Ki Bong ; Lee, Juneyoung ; Roh, Jae Kyu. / Correlation of coronary and cerebral atherosclerosis : Difference between extracranial and intracranial arteries. In: Cerebrovascular Diseases. 2006 ; Vol. 21, No. 1-2. pp. 112-119.
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AU - Koo, Ja Seong

AU - Lee, Seung Hoon

AU - Kim, Ki Bong

AU - Lee, Juneyoung

AU - Roh, Jae Kyu

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N2 - Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.

AB - Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.

KW - Carotid atherosclerosis

KW - Coronary artery bypass

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