Abstract
Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 112-119 |
| Number of pages | 8 |
| Journal | Cerebrovascular Diseases |
| Volume | 21 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2006 Jan 1 |
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Keywords
- Carotid atherosclerosis
- Coronary artery bypass
- Coronary atherosclerosis
- Intracranial atherosclerosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Correlation of coronary and cerebral atherosclerosis : Difference between extracranial and intracranial arteries. / Bae, Hee Joon; Yoon, Byung Woo; Kang, Dong Wha; Koo, Ja Seong; Lee, Seung Hoon; Kim, Ki Bong; Lee, Juneyoung; Roh, Jae Kyu.
In: Cerebrovascular Diseases, Vol. 21, No. 1-2, 01.01.2006, p. 112-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of coronary and cerebral atherosclerosis
T2 - Difference between extracranial and intracranial arteries
AU - Bae, Hee Joon
AU - Yoon, Byung Woo
AU - Kang, Dong Wha
AU - Koo, Ja Seong
AU - Lee, Seung Hoon
AU - Kim, Ki Bong
AU - Lee, Juneyoung
AU - Roh, Jae Kyu
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.
AB - Background: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. Methods: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. Results: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62 ± 4.80 vs. 9.45 ± 4.25; p = 0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41 ± 4.44 vs. 9.66 ± 4.49; p = 0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. Conclusions: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.
KW - Carotid atherosclerosis
KW - Coronary artery bypass
KW - Coronary atherosclerosis
KW - Intracranial atherosclerosis
UR - http://www.scopus.com/inward/record.url?scp=30944437998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30944437998&partnerID=8YFLogxK
U2 - 10.1159/000090209
DO - 10.1159/000090209
M3 - Article
C2 - 16340186
AN - SCOPUS:30944437998
VL - 21
SP - 112
EP - 119
JO - Cerebrovascular Diseases
JF - Cerebrovascular Diseases
SN - 1015-9770
IS - 1-2
ER -