Correlation of coronary artery atherosclerosis with atherosclerosis of the intracranial cerebral artery and the extracranial carotid artery

Woo Keun Seo, Hwan-Seok Yong, Seong Beom Koh, Sang-Il Suh, Ji H. Kim, Sungwook Yu, Ji Yeon Lee

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Investigating atherosclerosis of the coronary artery in ischemic stroke patients is clinically important because comorbidity is relatively common in such patients. We studied the relationship of atherosclerosis of the coronary artery to atherosclerosis of the intracranial cerebral artery and extracranial carotid artery. Further investigation was performed for determining the factors independently associated with coronary artery atherosclerosis in ischemic stroke patients. Methods: We consecutively recruited ischemic stroke patients who had no history of coronary artery disease, and they underwent vascular examination. Patient-based vascular assessment was performed with magnetic resonance angiography of the cerebral arteries and computed tomography coronary angiography. The factors independently associated with coronary artery stenosis (≥50%) were obtained from the conventional vascular risk factors and cerebral arterial stenosis using the logistic regression model. Results: Coronary artery stenosis was observed in 25.4% of the patients and this was associated with age (OR: 1.16, 95% CI: 1.03-1.30) and the presence of stenosis of the extracranial carotid artery (OR: 11.37, 95% CI: 1.88-68.75) after logistic regression analysis. Intracranial arterial stenosis was not independently related to coronary stenosis. Conclusion: Careful concern about coronary artery disease is needed when treating ischemic stroke patients who have atherosclerosis of the extracranial carotid artery.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalEuropean Neurology
Volume59
Issue number6
DOIs
Publication statusPublished - 2008 Apr 1

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Intracranial Arteriosclerosis
Cerebral Arteries
Carotid Arteries
Coronary Artery Disease
Coronary Vessels
Coronary Stenosis
Stroke
Atherosclerosis
Logistic Models
Blood Vessels
Pathologic Constriction
Magnetic Resonance Angiography
Carotid Stenosis
Coronary Angiography
Comorbidity
Regression Analysis

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • CT coronary angiography
  • Ischemic stroke
  • Magnetic resonance angiography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

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title = "Correlation of coronary artery atherosclerosis with atherosclerosis of the intracranial cerebral artery and the extracranial carotid artery",
abstract = "Background: Investigating atherosclerosis of the coronary artery in ischemic stroke patients is clinically important because comorbidity is relatively common in such patients. We studied the relationship of atherosclerosis of the coronary artery to atherosclerosis of the intracranial cerebral artery and extracranial carotid artery. Further investigation was performed for determining the factors independently associated with coronary artery atherosclerosis in ischemic stroke patients. Methods: We consecutively recruited ischemic stroke patients who had no history of coronary artery disease, and they underwent vascular examination. Patient-based vascular assessment was performed with magnetic resonance angiography of the cerebral arteries and computed tomography coronary angiography. The factors independently associated with coronary artery stenosis (≥50{\%}) were obtained from the conventional vascular risk factors and cerebral arterial stenosis using the logistic regression model. Results: Coronary artery stenosis was observed in 25.4{\%} of the patients and this was associated with age (OR: 1.16, 95{\%} CI: 1.03-1.30) and the presence of stenosis of the extracranial carotid artery (OR: 11.37, 95{\%} CI: 1.88-68.75) after logistic regression analysis. Intracranial arterial stenosis was not independently related to coronary stenosis. Conclusion: Careful concern about coronary artery disease is needed when treating ischemic stroke patients who have atherosclerosis of the extracranial carotid artery.",
keywords = "Atherosclerosis, Coronary artery disease, CT coronary angiography, Ischemic stroke, Magnetic resonance angiography",
author = "Seo, {Woo Keun} and Hwan-Seok Yong and Koh, {Seong Beom} and Sang-Il Suh and Kim, {Ji H.} and Sungwook Yu and Lee, {Ji Yeon}",
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T1 - Correlation of coronary artery atherosclerosis with atherosclerosis of the intracranial cerebral artery and the extracranial carotid artery

AU - Seo, Woo Keun

AU - Yong, Hwan-Seok

AU - Koh, Seong Beom

AU - Suh, Sang-Il

AU - Kim, Ji H.

AU - Yu, Sungwook

AU - Lee, Ji Yeon

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Background: Investigating atherosclerosis of the coronary artery in ischemic stroke patients is clinically important because comorbidity is relatively common in such patients. We studied the relationship of atherosclerosis of the coronary artery to atherosclerosis of the intracranial cerebral artery and extracranial carotid artery. Further investigation was performed for determining the factors independently associated with coronary artery atherosclerosis in ischemic stroke patients. Methods: We consecutively recruited ischemic stroke patients who had no history of coronary artery disease, and they underwent vascular examination. Patient-based vascular assessment was performed with magnetic resonance angiography of the cerebral arteries and computed tomography coronary angiography. The factors independently associated with coronary artery stenosis (≥50%) were obtained from the conventional vascular risk factors and cerebral arterial stenosis using the logistic regression model. Results: Coronary artery stenosis was observed in 25.4% of the patients and this was associated with age (OR: 1.16, 95% CI: 1.03-1.30) and the presence of stenosis of the extracranial carotid artery (OR: 11.37, 95% CI: 1.88-68.75) after logistic regression analysis. Intracranial arterial stenosis was not independently related to coronary stenosis. Conclusion: Careful concern about coronary artery disease is needed when treating ischemic stroke patients who have atherosclerosis of the extracranial carotid artery.

AB - Background: Investigating atherosclerosis of the coronary artery in ischemic stroke patients is clinically important because comorbidity is relatively common in such patients. We studied the relationship of atherosclerosis of the coronary artery to atherosclerosis of the intracranial cerebral artery and extracranial carotid artery. Further investigation was performed for determining the factors independently associated with coronary artery atherosclerosis in ischemic stroke patients. Methods: We consecutively recruited ischemic stroke patients who had no history of coronary artery disease, and they underwent vascular examination. Patient-based vascular assessment was performed with magnetic resonance angiography of the cerebral arteries and computed tomography coronary angiography. The factors independently associated with coronary artery stenosis (≥50%) were obtained from the conventional vascular risk factors and cerebral arterial stenosis using the logistic regression model. Results: Coronary artery stenosis was observed in 25.4% of the patients and this was associated with age (OR: 1.16, 95% CI: 1.03-1.30) and the presence of stenosis of the extracranial carotid artery (OR: 11.37, 95% CI: 1.88-68.75) after logistic regression analysis. Intracranial arterial stenosis was not independently related to coronary stenosis. Conclusion: Careful concern about coronary artery disease is needed when treating ischemic stroke patients who have atherosclerosis of the extracranial carotid artery.

KW - Atherosclerosis

KW - Coronary artery disease

KW - CT coronary angiography

KW - Ischemic stroke

KW - Magnetic resonance angiography

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