Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy

Ji Hyun Kim; Ki Chun Im; Jae Seung Kim; Sang Ahm Lee; Joong Koo Kang

doi:10.1097/00001756-200508010-00004

Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy

Ji Hyun Kim, Ki Chun Im, Jae Seung Kim, Sang Ahm Lee, Joong Koo Kang

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.

Original language	English
Pages (from-to)	1151-1155
Number of pages	5
Journal	Neuroreport
Volume	16
Issue number	11
DOIs	https://doi.org/10.1097/00001756-200508010-00004
Publication status	Published - 2005 Aug 1
Externally published	Yes

Keywords

Generalized spike-wave
Glucose metabolism
Juvenile myoclonic epilepsy
Positron emission tomography
Thalamus

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200508010-00004

Cite this

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title = "Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy",

abstract = "The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.",

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AU - Kim, Ji Hyun

AU - Im, Ki Chun

AU - Kim, Jae Seung

AU - Lee, Sang Ahm

AU - Kang, Joong Koo

PY - 2005/8/1

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N2 - The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.

AB - The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.

KW - Generalized spike-wave

KW - Glucose metabolism

KW - Juvenile myoclonic epilepsy

KW - Positron emission tomography

KW - Thalamus

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Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy

Abstract

Keywords

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