Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy

Ji Hyun Kim, Ki Chun Im, Jae Seung Kim, Sang Ahm Lee, Joong Koo Kang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.

Original languageEnglish
Pages (from-to)1151-1155
Number of pages5
JournalNeuroReport
Volume16
Issue number11
DOIs
Publication statusPublished - 2005 Aug 1
Externally publishedYes

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Keywords

  • Generalized spike-wave
  • Glucose metabolism
  • Juvenile myoclonic epilepsy
  • Positron emission tomography
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

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