TY - JOUR
T1 - Correlation of serum interleukin-31 with pruritus and blood eosinophil markers in children with atopic dermatitis
AU - Byeon, Jung Hye
AU - Yoon, Wonsuck
AU - Ahn, So Hyun
AU - Lee, Hyo Sun
AU - Kim, Seunghyun
AU - Yoo, Young
N1 - Funding Information:
From the 1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea, 2Allergy Immunology Center, Korea University, Seoul, Korea, and 3Environmental Health Center, Korea University Anam Hospital, Seoul, Korea This research was supported in part by Environmental Health Center for Childhood Asthma funded by the Ministry of Environment, Korea, by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Korea (NRF-2018R1A6A3A11049961, NRF-2019R1F1A1041169), by a grant of the Korea University to W. Yoon and Y. Yoo, and by Korea University Hospital Hin Moe (Prof. Hyun-Gum Lee) Research Fund. The authors have no conflicts of interest to declare pertaining to this article Address correspondence to Young Yoo, M.D., Department of Pediatrics, Korea University Anam Hospital, 73 Inchon-ro, Sungbuk-gu, Seoul 02841, Korea E-mail address: yoolina@korea.ac.kr Copyright © 2020, OceanSide Publications, Inc., U.S.A.
Publisher Copyright:
© 2020, OceanSide Publications, Inc., U.S.A.
PY - 2020
Y1 - 2020
N2 - Background: Atopic dermatitis (AD) is chronic pruritic inflammatory skin disease in children. Interleukin (IL) 31 is a recently discovered cytokine associated with chronic skin inflammation and pruritus. Objectives: The aims of this study were to determine whether serum IL-31 levels are increased in children with AD and to examine the relationship between IL-31 and other clinical biomarkers in AD. Methods: Serum cytokine levels, including IL-31, IL-4, and IL-12, were measured in 38 patients with AD and 10 healthy children. Peripheral blood eosinophils, serum immunoglobulin E levels, eosinophil cationic protein, and thymic stromal lymphopoietin (TSLP) were measured. We also estimated the clinical severity of AD by using the Scoring Atopic Dermatitis (SCORAD) index by a single clinician. Results: The serum IL-31 levels were significantly higher in the patients with AD than in the healthy children. IL-31 correlated well with the SCORAD index and blood eosinophilic inflammatory markers. The serum level of TSLP was also higher in patients with AD than in the healthy children; however, levels of IL-4 and IL-12 were not different between AD and healthy children. There was no significant difference in serum IL-31 levels between patients with atopic AD and nonatopic AD. Conclusion: This study showed that serum IL-31 levels were significantly elevated in patients with AD than in the healthy children and correlated well with disease severity. IL-31 seemed to be one of the cytokines that induce pruritus and eosinophilic inflammation in AD. Serum IL-31 correlated with pruritic symptoms and disease course of AD.
AB - Background: Atopic dermatitis (AD) is chronic pruritic inflammatory skin disease in children. Interleukin (IL) 31 is a recently discovered cytokine associated with chronic skin inflammation and pruritus. Objectives: The aims of this study were to determine whether serum IL-31 levels are increased in children with AD and to examine the relationship between IL-31 and other clinical biomarkers in AD. Methods: Serum cytokine levels, including IL-31, IL-4, and IL-12, were measured in 38 patients with AD and 10 healthy children. Peripheral blood eosinophils, serum immunoglobulin E levels, eosinophil cationic protein, and thymic stromal lymphopoietin (TSLP) were measured. We also estimated the clinical severity of AD by using the Scoring Atopic Dermatitis (SCORAD) index by a single clinician. Results: The serum IL-31 levels were significantly higher in the patients with AD than in the healthy children. IL-31 correlated well with the SCORAD index and blood eosinophilic inflammatory markers. The serum level of TSLP was also higher in patients with AD than in the healthy children; however, levels of IL-4 and IL-12 were not different between AD and healthy children. There was no significant difference in serum IL-31 levels between patients with atopic AD and nonatopic AD. Conclusion: This study showed that serum IL-31 levels were significantly elevated in patients with AD than in the healthy children and correlated well with disease severity. IL-31 seemed to be one of the cytokines that induce pruritus and eosinophilic inflammation in AD. Serum IL-31 correlated with pruritic symptoms and disease course of AD.
UR - http://www.scopus.com/inward/record.url?scp=85077337386&partnerID=8YFLogxK
U2 - 10.2500/aap.2020.41.190016
DO - 10.2500/aap.2020.41.190016
M3 - Article
C2 - 31888784
AN - SCOPUS:85077337386
SN - 1088-5412
VL - 41
SP - 59
EP - 65
JO - New England and regional allergy proceedings
JF - New England and regional allergy proceedings
IS - 1
ER -