Abstract
Background and purpose. Ultrasound has been used successfully to differentiate benign and malignant breast lesions. The aim of this study was to investigate the correlation between ultrasound and prognostic indicators in breast cancer such as histological type, tumor grade, and biological markers. Materials and methods. Ultrasound findings (shape, margin, orientation, boundary, echo pattern, posterior acoustic feature, and presence of calcifications) of 458 breast cancers were analyzed and correlated with the tumor type, tumor grade, and biological markers by univariate and multivariate logistic regression analyses. The biological markers were estrogen receptor, progesterone receptor, and HER-2/neu. Results. Invasive cancers displayed more frequently an irregular shape, a not parallel orientation, and a hypoechoic or complex echo pattern than carcinoma in situ cases (p<0.05). Poorly differentiated invasive cancers had more frequently not circumscribed margins, an abrupt boundary, and a hypoechoic or complex echo pattern than moderately/well differentiated cancers (p<0.05). Estrogen or progesterone receptor negative cancers more often displayed a hypoechoic or complex echo pattern and HER-2/neu positive cancers had more calcifications (p<0.05). Conclusion. Ultrasound pattern is correlated with tumor type, tumor grade, and biological markers in breast cancers and it may be useful for prediction of prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1531-1538 |
| Number of pages | 8 |
| Journal | Acta Oncologica |
| Volume | 47 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2008 Oct 28 |
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ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Hematology
Cite this
Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer. / Kim, Sung Hyun; Seo, Bo Kyoung; Lee, Juneyoung; Kim, Seok Jin; Cho, Kyu Ran; Lee, Ki Yeol; Je, Bo-Kyung; Kim, Hee Young; Kim, Young Sik; Lee, Ju-Han.
In: Acta Oncologica, Vol. 47, No. 8, 28.10.2008, p. 1531-1538.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer
AU - Kim, Sung Hyun
AU - Seo, Bo Kyoung
AU - Lee, Juneyoung
AU - Kim, Seok Jin
AU - Cho, Kyu Ran
AU - Lee, Ki Yeol
AU - Je, Bo-Kyung
AU - Kim, Hee Young
AU - Kim, Young Sik
AU - Lee, Ju-Han
PY - 2008/10/28
Y1 - 2008/10/28
N2 - Background and purpose. Ultrasound has been used successfully to differentiate benign and malignant breast lesions. The aim of this study was to investigate the correlation between ultrasound and prognostic indicators in breast cancer such as histological type, tumor grade, and biological markers. Materials and methods. Ultrasound findings (shape, margin, orientation, boundary, echo pattern, posterior acoustic feature, and presence of calcifications) of 458 breast cancers were analyzed and correlated with the tumor type, tumor grade, and biological markers by univariate and multivariate logistic regression analyses. The biological markers were estrogen receptor, progesterone receptor, and HER-2/neu. Results. Invasive cancers displayed more frequently an irregular shape, a not parallel orientation, and a hypoechoic or complex echo pattern than carcinoma in situ cases (p<0.05). Poorly differentiated invasive cancers had more frequently not circumscribed margins, an abrupt boundary, and a hypoechoic or complex echo pattern than moderately/well differentiated cancers (p<0.05). Estrogen or progesterone receptor negative cancers more often displayed a hypoechoic or complex echo pattern and HER-2/neu positive cancers had more calcifications (p<0.05). Conclusion. Ultrasound pattern is correlated with tumor type, tumor grade, and biological markers in breast cancers and it may be useful for prediction of prognosis.
AB - Background and purpose. Ultrasound has been used successfully to differentiate benign and malignant breast lesions. The aim of this study was to investigate the correlation between ultrasound and prognostic indicators in breast cancer such as histological type, tumor grade, and biological markers. Materials and methods. Ultrasound findings (shape, margin, orientation, boundary, echo pattern, posterior acoustic feature, and presence of calcifications) of 458 breast cancers were analyzed and correlated with the tumor type, tumor grade, and biological markers by univariate and multivariate logistic regression analyses. The biological markers were estrogen receptor, progesterone receptor, and HER-2/neu. Results. Invasive cancers displayed more frequently an irregular shape, a not parallel orientation, and a hypoechoic or complex echo pattern than carcinoma in situ cases (p<0.05). Poorly differentiated invasive cancers had more frequently not circumscribed margins, an abrupt boundary, and a hypoechoic or complex echo pattern than moderately/well differentiated cancers (p<0.05). Estrogen or progesterone receptor negative cancers more often displayed a hypoechoic or complex echo pattern and HER-2/neu positive cancers had more calcifications (p<0.05). Conclusion. Ultrasound pattern is correlated with tumor type, tumor grade, and biological markers in breast cancers and it may be useful for prediction of prognosis.
UR - http://www.scopus.com/inward/record.url?scp=54349095431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54349095431&partnerID=8YFLogxK
U2 - 10.1080/02841860801971413
DO - 10.1080/02841860801971413
M3 - Article
C2 - 18607848
AN - SCOPUS:54349095431
VL - 47
SP - 1531
EP - 1538
JO - Acta Oncologica
JF - Acta Oncologica
SN - 0284-186X
IS - 8
ER -