Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer

Sung Hyun Kim, Bo Kyoung Seo, Juneyoung Lee, Seok Jin Kim, Kyu Ran Cho, Ki Yeol Lee, Bo-Kyung Je, Hee Young Kim, Young Sik Kim, Ju-Han Lee

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background and purpose. Ultrasound has been used successfully to differentiate benign and malignant breast lesions. The aim of this study was to investigate the correlation between ultrasound and prognostic indicators in breast cancer such as histological type, tumor grade, and biological markers. Materials and methods. Ultrasound findings (shape, margin, orientation, boundary, echo pattern, posterior acoustic feature, and presence of calcifications) of 458 breast cancers were analyzed and correlated with the tumor type, tumor grade, and biological markers by univariate and multivariate logistic regression analyses. The biological markers were estrogen receptor, progesterone receptor, and HER-2/neu. Results. Invasive cancers displayed more frequently an irregular shape, a not parallel orientation, and a hypoechoic or complex echo pattern than carcinoma in situ cases (p<0.05). Poorly differentiated invasive cancers had more frequently not circumscribed margins, an abrupt boundary, and a hypoechoic or complex echo pattern than moderately/well differentiated cancers (p<0.05). Estrogen or progesterone receptor negative cancers more often displayed a hypoechoic or complex echo pattern and HER-2/neu positive cancers had more calcifications (p<0.05). Conclusion. Ultrasound pattern is correlated with tumor type, tumor grade, and biological markers in breast cancers and it may be useful for prediction of prognosis.

Original languageEnglish
Pages (from-to)1531-1538
Number of pages8
JournalActa Oncologica
Volume47
Issue number8
DOIs
Publication statusPublished - 2008 Oct 28

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Tumor Biomarkers
Histology
Breast Neoplasms
Neoplasms
Progesterone Receptors
Estrogen Receptors
Carcinoma in Situ
Acoustics
Breast
Biomarkers
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Correlation of ultrasound findings with histology, tumor grade, and biological markers in breast cancer. / Kim, Sung Hyun; Seo, Bo Kyoung; Lee, Juneyoung; Kim, Seok Jin; Cho, Kyu Ran; Lee, Ki Yeol; Je, Bo-Kyung; Kim, Hee Young; Kim, Young Sik; Lee, Ju-Han.

In: Acta Oncologica, Vol. 47, No. 8, 28.10.2008, p. 1531-1538.

Research output: Contribution to journalArticle

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