Abstract
We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and controls. Array-comparative genomic hybridization was performed for three patients with chromosomal anomalies. Fifty-nine of 519 patients (11.37%) had Y-chromosome microdeletions. Microdeletions were found in 11.18% (51/456) of the non-obstructive azoospermic patients and in 12.7% (8/63) of the severely oligozoospermic patients. Eleven of 51 non-obstructive azoospermic patients with Y-chromosome microdeletions had multiple segmental deletions in the AZFb+c regions; four of these patients had chromosomal anomalies. Our sample from northeastern China had a higher frequency of microdeletions among severely oligozoospermic than among non-obstructive azoospermic males.
| Original language | English |
|---|---|
| Pages (from-to) | 2422-2431 |
| Number of pages | 10 |
| Journal | Genetics and molecular research : GMR |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 Jan 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
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Correlation of Y-chromosome multiple segmental deletions and chromosomal anomalies in non-obstructive azoospermic males from northeastern China. / Dai, R. L.; Wang, R. X.; Jin, J. L.; Niu, G. N.; Lee, Ji-Yun; Li, S. B.; Liu, R. Z.
In: Genetics and molecular research : GMR, Vol. 11, No. 3, 01.01.2012, p. 2422-2431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of Y-chromosome multiple segmental deletions and chromosomal anomalies in non-obstructive azoospermic males from northeastern China.
AU - Dai, R. L.
AU - Wang, R. X.
AU - Jin, J. L.
AU - Niu, G. N.
AU - Lee, Ji-Yun
AU - Li, S. B.
AU - Liu, R. Z.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and controls. Array-comparative genomic hybridization was performed for three patients with chromosomal anomalies. Fifty-nine of 519 patients (11.37%) had Y-chromosome microdeletions. Microdeletions were found in 11.18% (51/456) of the non-obstructive azoospermic patients and in 12.7% (8/63) of the severely oligozoospermic patients. Eleven of 51 non-obstructive azoospermic patients with Y-chromosome microdeletions had multiple segmental deletions in the AZFb+c regions; four of these patients had chromosomal anomalies. Our sample from northeastern China had a higher frequency of microdeletions among severely oligozoospermic than among non-obstructive azoospermic males.
AB - We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and controls. Array-comparative genomic hybridization was performed for three patients with chromosomal anomalies. Fifty-nine of 519 patients (11.37%) had Y-chromosome microdeletions. Microdeletions were found in 11.18% (51/456) of the non-obstructive azoospermic patients and in 12.7% (8/63) of the severely oligozoospermic patients. Eleven of 51 non-obstructive azoospermic patients with Y-chromosome microdeletions had multiple segmental deletions in the AZFb+c regions; four of these patients had chromosomal anomalies. Our sample from northeastern China had a higher frequency of microdeletions among severely oligozoospermic than among non-obstructive azoospermic males.
UR - http://www.scopus.com/inward/record.url?scp=84872059164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872059164&partnerID=8YFLogxK
U2 - 10.4238/2012.May.10.3
DO - 10.4238/2012.May.10.3
M3 - Article
C2 - 22614455
AN - SCOPUS:84872059164
VL - 11
SP - 2422
EP - 2431
JO - Genetics and Molecular Research
JF - Genetics and Molecular Research
SN - 1676-5680
IS - 3
ER -