Correlation of Y-chromosome multiple segmental deletions and chromosomal anomalies in non-obstructive azoospermic males from northeastern China.

R. L. Dai, R. X. Wang, J. L. Jin, G. N. Niu, Ji-Yun Lee, S. B. Li, R. Z. Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and controls. Array-comparative genomic hybridization was performed for three patients with chromosomal anomalies. Fifty-nine of 519 patients (11.37%) had Y-chromosome microdeletions. Microdeletions were found in 11.18% (51/456) of the non-obstructive azoospermic patients and in 12.7% (8/63) of the severely oligozoospermic patients. Eleven of 51 non-obstructive azoospermic patients with Y-chromosome microdeletions had multiple segmental deletions in the AZFb+c regions; four of these patients had chromosomal anomalies. Our sample from northeastern China had a higher frequency of microdeletions among severely oligozoospermic than among non-obstructive azoospermic males.

Original languageEnglish
Pages (from-to)2422-2431
Number of pages10
JournalGenetics and molecular research : GMR
Volume11
Issue number3
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

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Y Chromosome
China
Comparative Genomic Hybridization
Chromosomes
Polymerase Chain Reaction
Male sterility due to Y-chromosome deletions

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Correlation of Y-chromosome multiple segmental deletions and chromosomal anomalies in non-obstructive azoospermic males from northeastern China. / Dai, R. L.; Wang, R. X.; Jin, J. L.; Niu, G. N.; Lee, Ji-Yun; Li, S. B.; Liu, R. Z.

In: Genetics and molecular research : GMR, Vol. 11, No. 3, 01.01.2012, p. 2422-2431.

Research output: Contribution to journalArticle

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