Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis

Dong Won Lee, Dae Yeon Kim, Ji Hyuck Hong, Soo-Hong Seo, Young Chul Kye, Hyo Hyun Ahn

Research output: Contribution to journalArticle

Abstract

Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white-to-yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated. Furthermore, viable epidermal thickness, vessel lumen dimensions, existence and thickness of ortho- and parakeratosis, degree of sola elastosis, flag sign existence, and Roewert-Huber classification were measured as histologic findings. Red background did not show a significant correlation with vascular dimension or viable epidermal thickness. When targetoid sign was present, vascular dimension was significantly larger but showed no correlation with viable epidermal thickness, parakeratosis or orthokeratosis. Solar elastosis level was significantly higher when white-to-yellow scale was present. According to Spearman's correlation analysis, ortho/parakeratotic thickness showed correlations with each other. The negative correlation between viable epidermal thickness and vascular dimension was also shown. Roewert-Huber histologic AK classification showed no correlation with any factors we checked. Factors considered to be characteristic features of AK in dermoscopy seemed unassociated with histologic AK classification and additional research is needed to determine degree of dysplasia of AK lesions using dermoscopy.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalMicroscopy Research and Technique
Volume82
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Actinic Keratosis
Parakeratosis
Dermoscopy
Blood Vessels
hubs
Biopsy
Pigmentation
lesions
Skin
lumens
Research
vessels
grade

Keywords

  • actinic keratosis
  • dermoscopy
  • histopathology

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

Cite this

Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis. / Lee, Dong Won; Kim, Dae Yeon; Hong, Ji Hyuck; Seo, Soo-Hong; Kye, Young Chul; Ahn, Hyo Hyun.

In: Microscopy Research and Technique, Vol. 82, No. 1, 01.01.2019, p. 12-17.

Research output: Contribution to journalArticle

@article{50b35ac7f2244fdb931d650dd5c082f5,
title = "Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis",
abstract = "Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white-to-yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated. Furthermore, viable epidermal thickness, vessel lumen dimensions, existence and thickness of ortho- and parakeratosis, degree of sola elastosis, flag sign existence, and Roewert-Huber classification were measured as histologic findings. Red background did not show a significant correlation with vascular dimension or viable epidermal thickness. When targetoid sign was present, vascular dimension was significantly larger but showed no correlation with viable epidermal thickness, parakeratosis or orthokeratosis. Solar elastosis level was significantly higher when white-to-yellow scale was present. According to Spearman's correlation analysis, ortho/parakeratotic thickness showed correlations with each other. The negative correlation between viable epidermal thickness and vascular dimension was also shown. Roewert-Huber histologic AK classification showed no correlation with any factors we checked. Factors considered to be characteristic features of AK in dermoscopy seemed unassociated with histologic AK classification and additional research is needed to determine degree of dysplasia of AK lesions using dermoscopy.",
keywords = "actinic keratosis, dermoscopy, histopathology",
author = "Lee, {Dong Won} and Kim, {Dae Yeon} and Hong, {Ji Hyuck} and Soo-Hong Seo and Kye, {Young Chul} and Ahn, {Hyo Hyun}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/jemt.23043",
language = "English",
volume = "82",
pages = "12--17",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis

AU - Lee, Dong Won

AU - Kim, Dae Yeon

AU - Hong, Ji Hyuck

AU - Seo, Soo-Hong

AU - Kye, Young Chul

AU - Ahn, Hyo Hyun

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white-to-yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated. Furthermore, viable epidermal thickness, vessel lumen dimensions, existence and thickness of ortho- and parakeratosis, degree of sola elastosis, flag sign existence, and Roewert-Huber classification were measured as histologic findings. Red background did not show a significant correlation with vascular dimension or viable epidermal thickness. When targetoid sign was present, vascular dimension was significantly larger but showed no correlation with viable epidermal thickness, parakeratosis or orthokeratosis. Solar elastosis level was significantly higher when white-to-yellow scale was present. According to Spearman's correlation analysis, ortho/parakeratotic thickness showed correlations with each other. The negative correlation between viable epidermal thickness and vascular dimension was also shown. Roewert-Huber histologic AK classification showed no correlation with any factors we checked. Factors considered to be characteristic features of AK in dermoscopy seemed unassociated with histologic AK classification and additional research is needed to determine degree of dysplasia of AK lesions using dermoscopy.

AB - Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white-to-yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated. Furthermore, viable epidermal thickness, vessel lumen dimensions, existence and thickness of ortho- and parakeratosis, degree of sola elastosis, flag sign existence, and Roewert-Huber classification were measured as histologic findings. Red background did not show a significant correlation with vascular dimension or viable epidermal thickness. When targetoid sign was present, vascular dimension was significantly larger but showed no correlation with viable epidermal thickness, parakeratosis or orthokeratosis. Solar elastosis level was significantly higher when white-to-yellow scale was present. According to Spearman's correlation analysis, ortho/parakeratotic thickness showed correlations with each other. The negative correlation between viable epidermal thickness and vascular dimension was also shown. Roewert-Huber histologic AK classification showed no correlation with any factors we checked. Factors considered to be characteristic features of AK in dermoscopy seemed unassociated with histologic AK classification and additional research is needed to determine degree of dysplasia of AK lesions using dermoscopy.

KW - actinic keratosis

KW - dermoscopy

KW - histopathology

UR - http://www.scopus.com/inward/record.url?scp=85060829244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060829244&partnerID=8YFLogxK

U2 - 10.1002/jemt.23043

DO - 10.1002/jemt.23043

M3 - Article

C2 - 29676831

AN - SCOPUS:85060829244

VL - 82

SP - 12

EP - 17

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 1

ER -