Correlations between umbilical and maternal serum resistin levels and neonatal birth weight

Geum-Joon Cho, Sang Wook Yoo, Soon Cheol Hong, Min Jeong Oh, Tak Kim, Hai Joong Kim, Kyu Wan Lee, Sun Haeng Kim

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective. Resistin is a novel hormone secreted by human adipocytes and mononuclear cells. It is expressed in the human placenta, and has been postulated to play a role in the regulation of energy metabolism during pregnancy. However, correlations between umbilical and maternal serum resistin levels and neonatal birth weight remain poorly understood. The purpose of the study was to clarify the correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Materials and methods. This study included 37 healthy mothers, and their neonates. Resistin levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Results. The ranges of resistin levels for umbilical and maternal sera were 10.61-40.81 and 1.14-25.54 ng/ml, respectively. Mean umbilical serum resistin level (21.34 ± 1.07 ng/ml) was significantly higher than maternal serum resistin level (10.13 ± 1.12) (p <0.001). Umbilical serum resistin levels were positively correlated with maternal serum resistin levels (r = 0.607, p <0.001) and negatively with neonatal birth weight (r = 0.345, p = 0.037). No significant differences in resistin levels were discovered between the female and male neonates. In addition, there were no correlations between the umbilical resistin levels and maternal body mass indices, umbilical leptin levels, or insulin levels. Conclusions. It is suggested that resistin not only affects energy homeostasis by existing in high levels in the fetus, but may play an important role in controlling body weight through effective regulation of adipogenesis by negative feedback.

Original languageEnglish
Pages (from-to)1051-1056
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume85
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

Fingerprint

Resistin
Umbilicus
Birth Weight
Mothers
Serum
Umbilical Cord
Adipogenesis
Leptin
Adipocytes
Placenta
Energy Metabolism

Keywords

  • Neonatal birth weight
  • Umbilical cord resistin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Correlations between umbilical and maternal serum resistin levels and neonatal birth weight. / Cho, Geum-Joon; Yoo, Sang Wook; Hong, Soon Cheol; Oh, Min Jeong; Kim, Tak; Kim, Hai Joong; Lee, Kyu Wan; Kim, Sun Haeng.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 85, No. 9, 01.09.2006, p. 1051-1056.

Research output: Contribution to journalArticle

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