Corticosteroid treatment of pure red cell aplasia in a patient with hepatitis a

Research output: Contribution to journalArticle

Abstract

Secondary pure red cell aplasia (PRCA), as an extrahepatic manifestation of hepatitis A virus infection, has been reported on rare occasions. We report herein an unusual case of hepatitis A complicated by PRCA. In addition, we reviewed nine cases reported in the English literature. Our case of nonfulminant hepatitis A complicated by PRCA and hemolytic anemia was successfully treated with initial transfusion and corticosteroid therapy for 18 weeks. The patient's hematologic abnormalities and liver function tests re-normalized completely. We review clinical features and effective therapeutic strategies for this disease entity.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalActa Haematologica
Volume128
Issue number1
DOIs
Publication statusPublished - 2012 Jun 1

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Pure Red-Cell Aplasia
Hepatitis
Adrenal Cortex Hormones
Hepatitis A
Literature
Hepatitis A virus
Liver Function Tests
Hemolytic Anemia
Virus Diseases
Therapeutics

Keywords

  • Anemia
  • Corticosteroid
  • Hemolytic anemia
  • Hepatitis A
  • Pure red cell aplasia

ASJC Scopus subject areas

  • Hematology

Cite this

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abstract = "Secondary pure red cell aplasia (PRCA), as an extrahepatic manifestation of hepatitis A virus infection, has been reported on rare occasions. We report herein an unusual case of hepatitis A complicated by PRCA. In addition, we reviewed nine cases reported in the English literature. Our case of nonfulminant hepatitis A complicated by PRCA and hemolytic anemia was successfully treated with initial transfusion and corticosteroid therapy for 18 weeks. The patient's hematologic abnormalities and liver function tests re-normalized completely. We review clinical features and effective therapeutic strategies for this disease entity.",
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AU - Yoon, Young Kyung

AU - Park, Dae Won

AU - Sohn, Jang Wook

AU - Min, Ja Kim

AU - Kim, Insun

AU - Nam, Myung-Hyun

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AB - Secondary pure red cell aplasia (PRCA), as an extrahepatic manifestation of hepatitis A virus infection, has been reported on rare occasions. We report herein an unusual case of hepatitis A complicated by PRCA. In addition, we reviewed nine cases reported in the English literature. Our case of nonfulminant hepatitis A complicated by PRCA and hemolytic anemia was successfully treated with initial transfusion and corticosteroid therapy for 18 weeks. The patient's hematologic abnormalities and liver function tests re-normalized completely. We review clinical features and effective therapeutic strategies for this disease entity.

KW - Anemia

KW - Corticosteroid

KW - Hemolytic anemia

KW - Hepatitis A

KW - Pure red cell aplasia

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