Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter

Hyo Sung Jung; Ji Hye Han; Zee Hwan Kim; Chulhun Kang; Jong Seung Kim

doi:10.1021/ol2018856

Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter

Hyo Sung Jung, Ji Hye Han, Zee Hwan Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

212 Citations (Scopus)

Abstract

An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.

Original language	English
Pages (from-to)	5056-5059
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1021/ol2018856
Publication status	Published - 2011 Oct 7

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Jung, Hyo Sung

AU - Han, Ji Hye

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AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2011/10/7

Y1 - 2011/10/7

N2 - An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.

AB - An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.

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Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter

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