Coupled problems in computational modeling of the respiratory system

Lena Wiechert, Timon Rabczuk, Michael Gee, Robert Metzke, Wolfgang A. Wall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)


Biomechanical simulations are an important field of application for high performance computing due to the complexity and largeness of involved problems. This paper is concerned with coupled problems in the human respiratory system with emphasis on mechanical ventilation. In this context we focus on the modeling aspects of pulmonary alveoli and the lower airways. Our alveolar model is based on artificially generated random geometries and takes into account realistic tissue behavior as well as interfacial phenomena. On the part of the structural solver a smoothed aggregation algebraic multigrid method is used. For the first four generations of the bronchial tree, a geometry based on human computer tomography scans obtained from in-vivo experiments is employed. With the help of fluid-structure interaction simulations, flow patterns and airway wall stresses for normal breathing and mechanical ventilation of the healthy and diseased lung are investigated.

Original languageEnglish
Title of host publicationHigh Performance Computing on Vector Systems 2007
PublisherSpringer Science and Business Media, LLC
Number of pages22
ISBN (Print)9783540743835
Publication statusPublished - 2008
Event2007 7th Teraflop Workshop - Sendai, Japan
Duration: 2007 Nov 212007 Nov 22

Publication series

NameHigh Performance Computing on Vector Systems 2007


Other2007 7th Teraflop Workshop

ASJC Scopus subject areas

  • Software


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