COX-2 targeting indomethacin conjugated fluorescent probe

Hyeong Seok Kim, Taegun Park, Wen Xiu Ren, Ja Yun Lim, Miae Won, June Seok Heo, Seung Gwan Lee, Jong Seung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalDyes and Pigments
Volume150
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Fluorescent Dyes
Indomethacin
Cells
Fluorescence
Imaging techniques
Oxidative stress
Fibroblasts
Medicine
Monitoring

Keywords

  • Bioimaging
  • Cancer detection
  • COX-2 enzyme
  • Fluorescent imaging
  • Indomethacin

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

Cite this

Kim, H. S., Park, T., Ren, W. X., Lim, J. Y., Won, M., Heo, J. S., ... Kim, J. S. (2018). COX-2 targeting indomethacin conjugated fluorescent probe. Dyes and Pigments, 150, 261-266. https://doi.org/10.1016/j.dyepig.2017.11.053

COX-2 targeting indomethacin conjugated fluorescent probe. / Kim, Hyeong Seok; Park, Taegun; Ren, Wen Xiu; Lim, Ja Yun; Won, Miae; Heo, June Seok; Lee, Seung Gwan; Kim, Jong Seung.

In: Dyes and Pigments, Vol. 150, 01.03.2018, p. 261-266.

Research output: Contribution to journalArticle

Kim, HS, Park, T, Ren, WX, Lim, JY, Won, M, Heo, JS, Lee, SG & Kim, JS 2018, 'COX-2 targeting indomethacin conjugated fluorescent probe', Dyes and Pigments, vol. 150, pp. 261-266. https://doi.org/10.1016/j.dyepig.2017.11.053
Kim HS, Park T, Ren WX, Lim JY, Won M, Heo JS et al. COX-2 targeting indomethacin conjugated fluorescent probe. Dyes and Pigments. 2018 Mar 1;150:261-266. https://doi.org/10.1016/j.dyepig.2017.11.053
Kim, Hyeong Seok ; Park, Taegun ; Ren, Wen Xiu ; Lim, Ja Yun ; Won, Miae ; Heo, June Seok ; Lee, Seung Gwan ; Kim, Jong Seung. / COX-2 targeting indomethacin conjugated fluorescent probe. In: Dyes and Pigments. 2018 ; Vol. 150. pp. 261-266.
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