COX-2 targeting indomethacin conjugated fluorescent probe

Hyeong Seok Kim, Taegun Park, Wen Xiu Ren, Ja Yun Lim, Miae Won, June Seok Heo, Seung Gwan Lee, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalDyes and Pigments
Volume150
DOIs
Publication statusPublished - 2018 Mar

Keywords

  • Bioimaging
  • COX-2 enzyme
  • Cancer detection
  • Fluorescent imaging
  • Indomethacin

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

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