Craniospinal irradiation techniques

A dosimetric comparison of proton beams with standard and advanced photon radiotherapy

Myonggeun Yoon, Dong Ho Shin, Jinsung Kim, Jong Won Kim, Dae Woong Kim, Sung Yong Park, Se Byeong Lee, Joo Young Kim, Hyeon Jin Park, Byungkiu Park, Sang Hoon Shin

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the dosimetric benefits of advanced radiotherapy techniques for craniospinal irradiation in cancer in children. Methods and Materials: Craniospinal irradiation (CSI) using three-dimensional conformal radiotherapy (3D-CRT), tomotherapy (TOMO), and proton beam treatment (PBT) in the scattering mode was planned for each of 10 patients at our institution. Dosimetric benefits and organ-specific radiation-induced cancer risks were based on comparisons of dose-volume histograms (DVHs) and on the application of organ equivalent doses (OEDs), respectively. Results: When we analyzed the organ-at-risk volumes that received 30%, 60%, and 90% of the prescribed dose (PD), we found that PBT was superior to TOMO and 3D-CRT. On average, the doses delivered by PBT to the esophagus, stomach, liver, lung, pancreas, and kidney were 19.4 Gy, 0.6 Gy, 0.3 Gy, 2.5 Gy, 0.2 Gy, and 2.2 Gy for the PD of 36 Gy, respectively, which were significantly lower than the doses delivered by TOMO (22.9 Gy, 4.5 Gy, 6.1 Gy, 4.0 Gy, 13.3 Gy, and 4.9 Gy, respectively) and 3D-CRT (34.6 Gy, 3.6 Gy, 8.0 Gy, 4.6 Gy, 22.9 Gy, and 4.3 Gy, respectively). Although the average doses delivered by PBT to the chest and abdomen were significantly lower than those of 3D-CRT or TOMO, these differences were reduced in the head-and-neck region. OED calculations showed that the risk of secondary cancers in organs such as the stomach, lungs, thyroid, and pancreas was much higher when 3D-CRT or TOMO was used than when PBT was used. Conclusions: Compared with photon techniques, PBT showed improvements in most dosimetric parameters for CSI patients, with lower OEDs to organs at risk.

Original languageEnglish
Pages (from-to)637-646
Number of pages10
JournalInternational Journal of Radiation Oncology Biology Physics
Volume81
Issue number3
DOIs
Publication statusPublished - 2011 Nov 1
Externally publishedYes

Fingerprint

Craniospinal Irradiation
proton beams
Photons
Protons
radiation therapy
Radiotherapy
organs
dosage
irradiation
photons
Organs at Risk
Pancreas
pancreas
stomach
Stomach
Therapeutics
cancer
Radiation-Induced Neoplasms
Conformal Radiotherapy
Lung

Keywords

  • Organ equivalent dose
  • Proton
  • Secondary cancer risk
  • Tomotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Craniospinal irradiation techniques : A dosimetric comparison of proton beams with standard and advanced photon radiotherapy. / Yoon, Myonggeun; Shin, Dong Ho; Kim, Jinsung; Kim, Jong Won; Kim, Dae Woong; Park, Sung Yong; Lee, Se Byeong; Kim, Joo Young; Park, Hyeon Jin; Park, Byungkiu; Shin, Sang Hoon.

In: International Journal of Radiation Oncology Biology Physics, Vol. 81, No. 3, 01.11.2011, p. 637-646.

Research output: Contribution to journalArticle

Yoon, Myonggeun ; Shin, Dong Ho ; Kim, Jinsung ; Kim, Jong Won ; Kim, Dae Woong ; Park, Sung Yong ; Lee, Se Byeong ; Kim, Joo Young ; Park, Hyeon Jin ; Park, Byungkiu ; Shin, Sang Hoon. / Craniospinal irradiation techniques : A dosimetric comparison of proton beams with standard and advanced photon radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2011 ; Vol. 81, No. 3. pp. 637-646.
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