Creation of hierarchical micro/nano-porous TiO2 surface layer onto Ti implants for improved biocompatibility

Cheol Min Han, Hyoun Ee Kim, Young-Hag Koh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We created a hierarchical micro/nano-porous TiO2 surface layer onto a Ti substrate to enhance its biocompatibility by mimicking the hierarchical architecture of the native extracellular matrix. To accomplish this, a rough, micro-porous TiO2 layer with pore sizes in the range of 0.5-2μm was first formed on the surfaces of a Ti substrate using micro-arc oxidation (MAO) and then coated with a thin layer of pure Ti, ~0.5μm in thickness, using electron beam (e-beam) evaporation. Subsequently, anodic oxidation was conducted to create a uniform nano-porous TiO2 surface layer with a pore size of ~70nm on the micro-porous layer. This hierarchical micro/nano-porous surface showed considerably enhanced hydrophilicity and in vitro biocompatibility compared to the dense surface and even the micro-porous and nano-porous surfaces. These improvements were attributed to the synergistic effect of micropores and nanopores created by a combination of MAO and anodic oxidation. In addition, protein adsorption capacity was remarkably improved due to the high affinity of the nano-porous TiO2 surface for proteins.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalSurface and Coatings Technology
Volume251
DOIs
Publication statusPublished - 2014 Jul 25

Fingerprint

biocompatibility
Biocompatibility
surface layers
oxidation
Anodic oxidation
arcs
Pore size
proteins
porosity
Oxidation
Nanopores
Proteins
Hydrophilicity
Substrates
affinity
evaporation
Electron beams
electron beams
Membrane Proteins
Evaporation

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Creation of hierarchical micro/nano-porous TiO2 surface layer onto Ti implants for improved biocompatibility. / Han, Cheol Min; Kim, Hyoun Ee; Koh, Young-Hag.

In: Surface and Coatings Technology, Vol. 251, 25.07.2014, p. 226-231.

Research output: Contribution to journalArticle

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