Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method

Seung Hyuk Im, Su Jeong Park, Justin J. Chung, Youngmee Jung, Soo Hyun Kim

Research output: Contribution to journalArticle

Abstract

Tubular scaffolds have been commonly used for vascular stents, grafts, and replacement of the trachea. Common scaffolds are built from non-biodegradable synthetic polymers that have superior mechanical properties; these polymers include expanded poly(tetrafluoroethylene), poly(ethylene terephthalate), and poly(urethane). Unfortunately, biodegradable polymers are rarely used for vascular scaffolds due to their inferior mechanical properties. To overcome the current limitations of biodegradable tubular scaffolds, a novel polymer melt-tube drawing (MD) process that allows the fabrication of biodegradable vascular scaffolds with high compressive strength has been developed. The machine designed for the MD process uses a combination of melt extrusion and tube-drawing. In comparison to the scaffold prepared by conventional techniques, the poly(lactide) tubular scaffold fabricated using the MD process showed improved compressive strength and recovery ability as well as a smooth surface. Furthermore, the MD-tube displayed extensive chain orientation and increased crystallinity. As a result, this novel MD process has the potential to permit fabrication of biodegradable vascular scaffolds with excellent mechanical properties. It provides an opportunity to greatly expand the application of biodegradable polymeric tubes.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalPolymer
Volume166
DOIs
Publication statusPublished - 2019 Mar 12

Fingerprint

Scaffolds
Compressive strength
Mechanical properties
Polymers
Fabrication
Biodegradable polymers
Polyethylene Terephthalates
Stents
poly(lactide)
Polymer melts
Urethane
Polytetrafluoroethylenes
Grafts
Polyethylene terephthalates
Extrusion
Recovery

Keywords

  • Melt-tube drawing
  • Polylactide
  • Tubular scaffold

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method. / Im, Seung Hyuk; Park, Su Jeong; Chung, Justin J.; Jung, Youngmee; Kim, Soo Hyun.

In: Polymer, Vol. 166, 12.03.2019, p. 130-137.

Research output: Contribution to journalArticle

Im, Seung Hyuk ; Park, Su Jeong ; Chung, Justin J. ; Jung, Youngmee ; Kim, Soo Hyun. / Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method. In: Polymer. 2019 ; Vol. 166. pp. 130-137.
@article{cb0025d8d4ef4718840d831e4124b773,
title = "Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method",
abstract = "Tubular scaffolds have been commonly used for vascular stents, grafts, and replacement of the trachea. Common scaffolds are built from non-biodegradable synthetic polymers that have superior mechanical properties; these polymers include expanded poly(tetrafluoroethylene), poly(ethylene terephthalate), and poly(urethane). Unfortunately, biodegradable polymers are rarely used for vascular scaffolds due to their inferior mechanical properties. To overcome the current limitations of biodegradable tubular scaffolds, a novel polymer melt-tube drawing (MD) process that allows the fabrication of biodegradable vascular scaffolds with high compressive strength has been developed. The machine designed for the MD process uses a combination of melt extrusion and tube-drawing. In comparison to the scaffold prepared by conventional techniques, the poly(lactide) tubular scaffold fabricated using the MD process showed improved compressive strength and recovery ability as well as a smooth surface. Furthermore, the MD-tube displayed extensive chain orientation and increased crystallinity. As a result, this novel MD process has the potential to permit fabrication of biodegradable vascular scaffolds with excellent mechanical properties. It provides an opportunity to greatly expand the application of biodegradable polymeric tubes.",
keywords = "Melt-tube drawing, Polylactide, Tubular scaffold",
author = "Im, {Seung Hyuk} and Park, {Su Jeong} and Chung, {Justin J.} and Youngmee Jung and Kim, {Soo Hyun}",
year = "2019",
month = "3",
day = "12",
doi = "10.1016/j.polymer.2019.01.067",
language = "English",
volume = "166",
pages = "130--137",
journal = "Polymer (United Kingdom)",
issn = "0032-3861",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Creation of polylactide vascular scaffolds with high compressive strength using a novel melt-tube drawing method

AU - Im, Seung Hyuk

AU - Park, Su Jeong

AU - Chung, Justin J.

AU - Jung, Youngmee

AU - Kim, Soo Hyun

PY - 2019/3/12

Y1 - 2019/3/12

N2 - Tubular scaffolds have been commonly used for vascular stents, grafts, and replacement of the trachea. Common scaffolds are built from non-biodegradable synthetic polymers that have superior mechanical properties; these polymers include expanded poly(tetrafluoroethylene), poly(ethylene terephthalate), and poly(urethane). Unfortunately, biodegradable polymers are rarely used for vascular scaffolds due to their inferior mechanical properties. To overcome the current limitations of biodegradable tubular scaffolds, a novel polymer melt-tube drawing (MD) process that allows the fabrication of biodegradable vascular scaffolds with high compressive strength has been developed. The machine designed for the MD process uses a combination of melt extrusion and tube-drawing. In comparison to the scaffold prepared by conventional techniques, the poly(lactide) tubular scaffold fabricated using the MD process showed improved compressive strength and recovery ability as well as a smooth surface. Furthermore, the MD-tube displayed extensive chain orientation and increased crystallinity. As a result, this novel MD process has the potential to permit fabrication of biodegradable vascular scaffolds with excellent mechanical properties. It provides an opportunity to greatly expand the application of biodegradable polymeric tubes.

AB - Tubular scaffolds have been commonly used for vascular stents, grafts, and replacement of the trachea. Common scaffolds are built from non-biodegradable synthetic polymers that have superior mechanical properties; these polymers include expanded poly(tetrafluoroethylene), poly(ethylene terephthalate), and poly(urethane). Unfortunately, biodegradable polymers are rarely used for vascular scaffolds due to their inferior mechanical properties. To overcome the current limitations of biodegradable tubular scaffolds, a novel polymer melt-tube drawing (MD) process that allows the fabrication of biodegradable vascular scaffolds with high compressive strength has been developed. The machine designed for the MD process uses a combination of melt extrusion and tube-drawing. In comparison to the scaffold prepared by conventional techniques, the poly(lactide) tubular scaffold fabricated using the MD process showed improved compressive strength and recovery ability as well as a smooth surface. Furthermore, the MD-tube displayed extensive chain orientation and increased crystallinity. As a result, this novel MD process has the potential to permit fabrication of biodegradable vascular scaffolds with excellent mechanical properties. It provides an opportunity to greatly expand the application of biodegradable polymeric tubes.

KW - Melt-tube drawing

KW - Polylactide

KW - Tubular scaffold

UR - http://www.scopus.com/inward/record.url?scp=85060928644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060928644&partnerID=8YFLogxK

U2 - 10.1016/j.polymer.2019.01.067

DO - 10.1016/j.polymer.2019.01.067

M3 - Article

VL - 166

SP - 130

EP - 137

JO - Polymer (United Kingdom)

JF - Polymer (United Kingdom)

SN - 0032-3861

ER -