Critical closing pressure

Comparison of three methods

Jorge A. López-Magaña, Hugh K. Richards, Danila K. Radolovich, Dong Ju Kim, Peter Smielewski, Peter J. Kirkpatrick, John D. Pickard, Marek Czosnyka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Critical closing pressure (CCP) is an arterial pressure threshold below which small arterial vessels collapse. Our aim was to compare different methods to estimate CCP in the cerebrovascular circulation using the relationships between transcranial Doppler flow velocity (FV), laser-Doppler flux (LDF), and arterial blood pressure (ABP). A total of 116 experiments in rabbits were analyzed retrospectively. At the end of each recording, cardiac arrest (CA) was induced. Arterial blood pressure in femoral artery, basilar artery FV, cortical blood LDF, intracranial pressure (ICP) was recorded. Critical closing pressure was estimated using linear regression between decreasing mean ABP values, FV, and LDF during CA. In addition, CCP was calculated from FV waveform just before CA. The correlation between CCP evaluated using LDF and FV during CA was 0.98 (P0.0001). The correlation between CCP measured during CA and CCP estimated from the transcranial Doppler ultrasonography (TCD) waveform was weaker (R0.39; P0.001), with CCP calculated from waveform being significantly greater than CCP from CA (median difference 9mmHg; P0.003). Critical closing pressures obtained from FV waveform and CA correlated with mean ICP before CA (R0.40; P0.001). In conclusion strong correlation exists between CCP values obtained by means of FV and LDF during cardiac arrest. However, predictions of CCP using TCD waveform analysis show substantial differences from values of CCP recorded during cardiac arrest.

Original languageEnglish
Pages (from-to)987-993
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume29
Issue number5
DOIs
Publication statusPublished - 2009 May 1
Externally publishedYes

Fingerprint

Heart Arrest
Pressure
Arterial Pressure
Lasers
Doppler Transcranial Ultrasonography
Intracranial Pressure
Cerebrovascular Circulation
Induced Heart Arrest
Basilar Artery
Blood Flow Velocity
Femoral Artery
Linear Models
Rabbits

Keywords

  • Cerebral hemodynamic
  • Critical closing pressure
  • Experiment
  • laser-Doppler flowmetry
  • Ultrasonography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

López-Magaña, J. A., Richards, H. K., Radolovich, D. K., Kim, D. J., Smielewski, P., Kirkpatrick, P. J., ... Czosnyka, M. (2009). Critical closing pressure: Comparison of three methods. Journal of Cerebral Blood Flow and Metabolism, 29(5), 987-993. https://doi.org/10.1038/jcbfm.2009.24

Critical closing pressure : Comparison of three methods. / López-Magaña, Jorge A.; Richards, Hugh K.; Radolovich, Danila K.; Kim, Dong Ju; Smielewski, Peter; Kirkpatrick, Peter J.; Pickard, John D.; Czosnyka, Marek.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 29, No. 5, 01.05.2009, p. 987-993.

Research output: Contribution to journalArticle

López-Magaña, JA, Richards, HK, Radolovich, DK, Kim, DJ, Smielewski, P, Kirkpatrick, PJ, Pickard, JD & Czosnyka, M 2009, 'Critical closing pressure: Comparison of three methods', Journal of Cerebral Blood Flow and Metabolism, vol. 29, no. 5, pp. 987-993. https://doi.org/10.1038/jcbfm.2009.24
López-Magaña JA, Richards HK, Radolovich DK, Kim DJ, Smielewski P, Kirkpatrick PJ et al. Critical closing pressure: Comparison of three methods. Journal of Cerebral Blood Flow and Metabolism. 2009 May 1;29(5):987-993. https://doi.org/10.1038/jcbfm.2009.24
López-Magaña, Jorge A. ; Richards, Hugh K. ; Radolovich, Danila K. ; Kim, Dong Ju ; Smielewski, Peter ; Kirkpatrick, Peter J. ; Pickard, John D. ; Czosnyka, Marek. / Critical closing pressure : Comparison of three methods. In: Journal of Cerebral Blood Flow and Metabolism. 2009 ; Vol. 29, No. 5. pp. 987-993.
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