Abstract
Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.
| Original language | English |
|---|---|
| Pages (from-to) | 728-731 |
| Number of pages | 4 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 57 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1998 Jan 1 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
- Biochemistry, Genetics and Molecular Biology(all)
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Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection. / Lee, Young Ho; Ji, Jong Dae; Yeon, Jong Eun; Byun, Kwan Soo; Lee, Chang Hong; Song, Gwan Gyu.
In: Annals of the Rheumatic Diseases, Vol. 57, No. 12, 01.01.1998, p. 728-731.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection
AU - Lee, Young Ho
AU - Ji, Jong Dae
AU - Yeon, Jong Eun
AU - Byun, Kwan Soo
AU - Lee, Chang Hong
AU - Song, Gwan Gyu
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.
AB - Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.
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U2 - 10.1136/ard.57.12.728
DO - 10.1136/ard.57.12.728
M3 - Article
VL - 57
SP - 728
EP - 731
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 12
ER -