Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection

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Abstract

Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.

Original languageEnglish
Pages (from-to)728-731
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume57
Issue number12
DOIs
Publication statusPublished - 1998 Jan 1

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Cryoglobulinemia
Virus Diseases
GB virus C
Viruses
Hepacivirus
Cryoglobulins
Rheumatoid Factor
Antinuclear Antibodies
Genotype
Polymerase chain reaction
Oral Ulcer
Skin Manifestations
Liver
Raynaud Disease
Paresthesia
Liver Cirrhosis
Abdominal Pain
Mouth

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{7519a2f16cf641e9a30fcbbb6488443b,
title = "Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection",
abstract = "Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59{\%} in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80{\%}) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14{\%} and 3.4{\%} respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35{\%}), cutaneous manifestation (37{\%}), Raynaud's phenomenon (8{\%}), paresthesia (44{\%}), dry eyes (22{\%}), dry mouth (10{\%}), oral ulcer (33{\%}), and abdominal pain (14{\%}). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.",
author = "Lee, {Young Ho} and Ji, {Jong Dae} and Yeon, {Jong Eun} and Byun, {Kwan Soo} and Lee, {Chang Hong} and Song, {Gwan Gyu}",
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T1 - Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection

AU - Lee, Young Ho

AU - Ji, Jong Dae

AU - Yeon, Jong Eun

AU - Byun, Kwan Soo

AU - Lee, Chang Hong

AU - Song, Gwan Gyu

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.

AB - Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis G virus (HGV) infection. Methods-Forty nine Korean patients with HGV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HGV genotype was determined by polymerase chain reaction with genotype specific primer. Results-The prevalence of cryoglobulin was 59% in Korean HGV patients and the concentration of cryoglobulin was 9.8 (7.9) g/1 (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HGV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HGV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HGV patients were as follows: arthralgialarthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. Conclusion-Although the rheumatological symptoms were not different between HGV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.

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U2 - 10.1136/ard.57.12.728

DO - 10.1136/ard.57.12.728

M3 - Article

VL - 57

SP - 728

EP - 731

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

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