CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US

Therapeutic Effectiveness and Safety

Beomjin Park, Jae Ho Byun, Yong Hyun Jin, Hyung Jin Won, Yong Moon Shin, Kyoung Won Kim, Sang Joon Park, Pyo Nyun Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.

Original languageEnglish
Pages (from-to)490-499
Number of pages10
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

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Hepatocellular Carcinoma
Ultrasonography
Tomography
Carcinoma
Safety
Pneumothorax
Electrodes
Therapeutics
Lung
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US : Therapeutic Effectiveness and Safety. / Park, Beomjin; Byun, Jae Ho; Jin, Yong Hyun; Won, Hyung Jin; Shin, Yong Moon; Kim, Kyoung Won; Park, Sang Joon; Kim, Pyo Nyun.

In: Journal of Vascular and Interventional Radiology, Vol. 20, No. 4, 01.04.2009, p. 490-499.

Research output: Contribution to journalArticle

Park, Beomjin ; Byun, Jae Ho ; Jin, Yong Hyun ; Won, Hyung Jin ; Shin, Yong Moon ; Kim, Kyoung Won ; Park, Sang Joon ; Kim, Pyo Nyun. / CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US : Therapeutic Effectiveness and Safety. In: Journal of Vascular and Interventional Radiology. 2009 ; Vol. 20, No. 4. pp. 490-499.
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abstract = "Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97{\%} (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97{\%} (94 of 97 HCCs), 94{\%} (91 of 97 HCCs), 84{\%} (81 of 96 HCCs), and 74{\%} (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7{\%}). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32{\%}) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.",
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AU - Jin, Yong Hyun

AU - Won, Hyung Jin

AU - Shin, Yong Moon

AU - Kim, Kyoung Won

AU - Park, Sang Joon

AU - Kim, Pyo Nyun

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N2 - Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.

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