CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US: Therapeutic Effectiveness and Safety

Beomjin Park, Jae Ho Byun, Yong Hyun Jin, Hyung Jin Won, Yong Moon Shin, Kyoung Won Kim, Sang Joon Park, Pyo Nyun Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.

Original languageEnglish
Pages (from-to)490-499
Number of pages10
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

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Hepatocellular Carcinoma
Ultrasonography
Tomography
Carcinoma
Safety
Pneumothorax
Electrodes
Therapeutics
Lung
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US : Therapeutic Effectiveness and Safety. / Park, Beomjin; Byun, Jae Ho; Jin, Yong Hyun; Won, Hyung Jin; Shin, Yong Moon; Kim, Kyoung Won; Park, Sang Joon; Kim, Pyo Nyun.

In: Journal of Vascular and Interventional Radiology, Vol. 20, No. 4, 01.04.2009, p. 490-499.

Research output: Contribution to journalArticle

Park, Beomjin ; Byun, Jae Ho ; Jin, Yong Hyun ; Won, Hyung Jin ; Shin, Yong Moon ; Kim, Kyoung Won ; Park, Sang Joon ; Kim, Pyo Nyun. / CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US : Therapeutic Effectiveness and Safety. In: Journal of Vascular and Interventional Radiology. 2009 ; Vol. 20, No. 4. pp. 490-499.
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abstract = "Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97{\%} (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97{\%} (94 of 97 HCCs), 94{\%} (91 of 97 HCCs), 84{\%} (81 of 96 HCCs), and 74{\%} (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7{\%}). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32{\%}) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.",
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AU - Jin, Yong Hyun

AU - Won, Hyung Jin

AU - Shin, Yong Moon

AU - Kim, Kyoung Won

AU - Park, Sang Joon

AU - Kim, Pyo Nyun

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N2 - Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.

AB - Purpose: To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods: CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3-39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results: The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax (P = .26). Conclusions: For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.

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