CT of chronic infiltrative lung disease: Prevalence of mediastinal lymphadenopathy

Hiroshi Niimi, Eun-Young Kang, J. Stephen Kwong, Stephane Carignan, Nestor L. Müller

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: Our goal was to determine the prevalence of mediastinal lymph node enlargement at CT in patients with diffuse infiltrative lung disease. Materials and Methods: The study was retrospective and included 175 consecutive patients with diffuse infiltrative lung diseases. Diagnoses included idiopathic pulmonary fibrosis (IPF) (n = 61), usual interstitial pneumonia associated with collagen vascular disease (CVD) (n = 20), idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) (n = 22), extrinsic allergic alveolitis (EAA) (n = 17), and sarcoidosis (n = 55). Fifty-eight age-matched patients with CT of the chest performed for unrelated conditions served as controls. The presence, number, and sites of enlarged nodes (short axis ≥10 mm in diameter) were recorded. Results: Enlarged mediastinal nodes were present in 118 of 175 patients (67%) with infiltrative lung disease and 3 of 58 controls (5%) (p < 0.001). The prevalence of enlarged nodes was 84% (46 of 55) in sarcoidosis, 67% (41 of 61) in IPF, 70% (14 of 20) in CVD, 53% (9 of 17) in EAA, and 36% (8 of 22) in BOOP. The mean number of enlarged nodes was higher in sarcoidosis (mean 3.2) than in the other infiltrative diseases (mean 1.2) (p < 0.001). Enlarged nodes were most commonly present in station 10R, followed by 7, 4R, and 5. Conclusion: Patients with infiltrative lung disease frequently have enlarged mediastinal lymph nodes. However, in diseases other than sarcoid, usually only one or two nodes are enlarged and their maximal short axis diameter is <15 mm.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalJournal of Computer Assisted Tomography
Volume20
Issue number2
DOIs
Publication statusPublished - 1996 Apr 22
Externally publishedYes

Fingerprint

Lung Diseases
Idiopathic Pulmonary Fibrosis
Sarcoidosis
Cryptogenic Organizing Pneumonia
Extrinsic Allergic Alveolitis
Collagen Diseases
Vascular Diseases
Lymph Nodes
Thorax
Retrospective Studies
Lymphadenopathy

Keywords

  • Computed tomography
  • Infiltrative lung diseases
  • Lungs, diseases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

CT of chronic infiltrative lung disease : Prevalence of mediastinal lymphadenopathy. / Niimi, Hiroshi; Kang, Eun-Young; Kwong, J. Stephen; Carignan, Stephane; Müller, Nestor L.

In: Journal of Computer Assisted Tomography, Vol. 20, No. 2, 22.04.1996, p. 305-308.

Research output: Contribution to journalArticle

Niimi, Hiroshi ; Kang, Eun-Young ; Kwong, J. Stephen ; Carignan, Stephane ; Müller, Nestor L. / CT of chronic infiltrative lung disease : Prevalence of mediastinal lymphadenopathy. In: Journal of Computer Assisted Tomography. 1996 ; Vol. 20, No. 2. pp. 305-308.
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abstract = "Objective: Our goal was to determine the prevalence of mediastinal lymph node enlargement at CT in patients with diffuse infiltrative lung disease. Materials and Methods: The study was retrospective and included 175 consecutive patients with diffuse infiltrative lung diseases. Diagnoses included idiopathic pulmonary fibrosis (IPF) (n = 61), usual interstitial pneumonia associated with collagen vascular disease (CVD) (n = 20), idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) (n = 22), extrinsic allergic alveolitis (EAA) (n = 17), and sarcoidosis (n = 55). Fifty-eight age-matched patients with CT of the chest performed for unrelated conditions served as controls. The presence, number, and sites of enlarged nodes (short axis ≥10 mm in diameter) were recorded. Results: Enlarged mediastinal nodes were present in 118 of 175 patients (67{\%}) with infiltrative lung disease and 3 of 58 controls (5{\%}) (p < 0.001). The prevalence of enlarged nodes was 84{\%} (46 of 55) in sarcoidosis, 67{\%} (41 of 61) in IPF, 70{\%} (14 of 20) in CVD, 53{\%} (9 of 17) in EAA, and 36{\%} (8 of 22) in BOOP. The mean number of enlarged nodes was higher in sarcoidosis (mean 3.2) than in the other infiltrative diseases (mean 1.2) (p < 0.001). Enlarged nodes were most commonly present in station 10R, followed by 7, 4R, and 5. Conclusion: Patients with infiltrative lung disease frequently have enlarged mediastinal lymph nodes. However, in diseases other than sarcoid, usually only one or two nodes are enlarged and their maximal short axis diameter is <15 mm.",
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