Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is characterized by varying degrees of involvement of airway and lung parenchyma. Although cigarette smoke is the major risk factor for COPD, the principal determining factors of involvement of the airway or lung parenchyma have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway and parenchyma. We therefore studied whether airway and parenchyma involvement might be associated with the ADRB2 genotype, which has been reported to be associated with COPD susceptibility and the bronchodilator response. Methods: One hundred and eleven COPD subjects, whose post-bronchodilator FEV1/FVC values were less than 0.7, and who had histories of smoking exceeding 10 pack-years, were prospectively recruited from pulmonology clinics of 11 hospitals in Seoul, Korea. The degrees of involvement of airway and parenchyma were evaluated by volumetric computed tomography (CT) scans. In-house software automatically calculated luminal areas, airway wall areas, percentages of wall areas in segmental bronchi, emphysema indices, and mean lung densities in the whole lung parenchyma. The ADRB2 genotypes at codon 16 were determined for all patients. Results: Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p = 0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype. Neither emphysema index nor mean lung density was associated with ADRB2 genotype. Conclusion: Gly16 variant in ADRB2 gene was associated with airway wall phenotypes measured using CT scanning in COPD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 98-103 |
| Number of pages | 6 |
| Journal | Respiratory Medicine |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 Jan 1 |
| Externally published | Yes |
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Keywords
- Computed tomography
- COPD
- Polymorphism
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease. / Kim, Woo Jin; Oh, Yeon Mok; Sung, Joohon; Lee, Young Kyung; Seo, Joon Beom; Kim, Nam Kug; Kim, Tae Hyung; Huh, Jin Won; Lee, Ji Hyun; Kim, Eun Kyung; Lee, Jin Hwa; Lee, Sang Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Kwon, Sung Youn; Lee, Sang Do.
In: Respiratory Medicine, Vol. 103, No. 1, 01.01.2009, p. 98-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease
AU - Kim, Woo Jin
AU - Oh, Yeon Mok
AU - Sung, Joohon
AU - Lee, Young Kyung
AU - Seo, Joon Beom
AU - Kim, Nam Kug
AU - Kim, Tae Hyung
AU - Huh, Jin Won
AU - Lee, Ji Hyun
AU - Kim, Eun Kyung
AU - Lee, Jin Hwa
AU - Lee, Sang Min
AU - Lee, Sang Yeub
AU - Lim, Seong Yong
AU - Shin, Tae Rim
AU - Yoon, Ho Il
AU - Kwon, Sung Youn
AU - Lee, Sang Do
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is characterized by varying degrees of involvement of airway and lung parenchyma. Although cigarette smoke is the major risk factor for COPD, the principal determining factors of involvement of the airway or lung parenchyma have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway and parenchyma. We therefore studied whether airway and parenchyma involvement might be associated with the ADRB2 genotype, which has been reported to be associated with COPD susceptibility and the bronchodilator response. Methods: One hundred and eleven COPD subjects, whose post-bronchodilator FEV1/FVC values were less than 0.7, and who had histories of smoking exceeding 10 pack-years, were prospectively recruited from pulmonology clinics of 11 hospitals in Seoul, Korea. The degrees of involvement of airway and parenchyma were evaluated by volumetric computed tomography (CT) scans. In-house software automatically calculated luminal areas, airway wall areas, percentages of wall areas in segmental bronchi, emphysema indices, and mean lung densities in the whole lung parenchyma. The ADRB2 genotypes at codon 16 were determined for all patients. Results: Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p = 0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype. Neither emphysema index nor mean lung density was associated with ADRB2 genotype. Conclusion: Gly16 variant in ADRB2 gene was associated with airway wall phenotypes measured using CT scanning in COPD patients.
AB - Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is characterized by varying degrees of involvement of airway and lung parenchyma. Although cigarette smoke is the major risk factor for COPD, the principal determining factors of involvement of the airway or lung parenchyma have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway and parenchyma. We therefore studied whether airway and parenchyma involvement might be associated with the ADRB2 genotype, which has been reported to be associated with COPD susceptibility and the bronchodilator response. Methods: One hundred and eleven COPD subjects, whose post-bronchodilator FEV1/FVC values were less than 0.7, and who had histories of smoking exceeding 10 pack-years, were prospectively recruited from pulmonology clinics of 11 hospitals in Seoul, Korea. The degrees of involvement of airway and parenchyma were evaluated by volumetric computed tomography (CT) scans. In-house software automatically calculated luminal areas, airway wall areas, percentages of wall areas in segmental bronchi, emphysema indices, and mean lung densities in the whole lung parenchyma. The ADRB2 genotypes at codon 16 were determined for all patients. Results: Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p = 0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype. Neither emphysema index nor mean lung density was associated with ADRB2 genotype. Conclusion: Gly16 variant in ADRB2 gene was associated with airway wall phenotypes measured using CT scanning in COPD patients.
KW - Computed tomography
KW - COPD
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=58049192957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58049192957&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2008.07.025
DO - 10.1016/j.rmed.2008.07.025
M3 - Article
C2 - 18789663
AN - SCOPUS:58049192957
VL - 103
SP - 98
EP - 103
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 1
ER -