CTLA-4 polymorphisms and susceptibility to Behcet's disease: A meta-analysis

Young Ho Lee, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphisms confer susceptibility to Behcet's disease (BD). A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms and BD using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 8 separate comparison studies on BD were considered in the meta-analysis. Meta-analysis of the CTLA-4 +49 A/G polymorphisms showed no association between BD and the CTLA-4 +49 G allele in all study subjects (odds ratio [OR] = 0.780, 95 % confidence interval [CI] = 0.491-1.240, p = 0.294). Moreover, stratification by ethnicity indicated no association between the CTLA-4 +49 G allele and BD in Turkish population. No association was found between BD and the CTLA-4 +49 A/G polymorphisms using recessive or dominant models or contrast of homozygotes. No association was found between BD and the CTLA-4 -318 C/T or CT60 A/G polymorphisms. This meta-analysis showed that no association was found between CTLA-4 +49 A/G, -318 C/T or CT60 A/G polymorphisms and BD.

    Original languageEnglish
    Pages (from-to)9041-9045
    Number of pages5
    JournalMolecular biology reports
    Volume39
    Issue number9
    DOIs
    Publication statusPublished - 2012 Sep

    Keywords

    • Behcet's disease
    • Cytotoxic T lymphocyte antigen-4
    • Meta-analysis
    • Polymorphism

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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