CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: A meta-analysis

Young Ho Lee, Jae Hoon Kim, Young Ho Seo, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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11 Citations (Scopus)

Abstract

Objective: The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). Methods: The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms, and (AT)n repeat in the 3' untranslated region (UTR) and UC and CD susceptibility. Results: A total of 15 comparison studies were considered in our meta-analysis. Meta-analysis revealed no association between UC and the CTLA-4 +49 G and CTLA-4 -318 T alleles in all subjects (OR=0.982, 95% CI=0.851-1.1339, p=0.804; OR=0.500, 95% CI=0.223-1.124, p=0.094). No association was found between UC and the CTLA-4 CT60 A/G polymorphism in Europeans. However, a significant association was observed between the longer allele (≥118bp) of the (AT)n and UC in Asian population (OR=6.073, 95% CI=4.246-8.684, p=1.0×10-9). Meta-analysis of the CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms showed no association with CD. Conclusions: This meta-analysis demonstrates that the CTLA-4 (AT)n repeat in 3' UTR may be associated with susceptibility to UC in Asians, while no association was found between the CTLA-4 +49 A/G, -318 C/T, and CD60 A/G polymorphism and susceptibility to UC and CD.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalHuman Immunology
Volume75
Issue number5
DOIs
Publication statusPublished - 2014 May

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Lee, Y. H., Kim, J. H., Seo, Y. H., Choi, S. J., Ji, J. D., & Song, G. G. (2014). CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: A meta-analysis. Human Immunology, 75(5), 414-421. https://doi.org/10.1016/j.humimm.2014.02.020