Curcumin as a putative antidepressant

Ho Jun Seo, Sheng Min Wang, Changsu Han, Soo Jung Lee, Ashwin A. Patkar, Prakash S. Masand, Chi Un Pae

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Due to inadequate efficacy of antidepressants, various new chemical entities and agents of natural origin have been tested for therapeutic efficacy both alone and to augment existing antidepressants, producing varied clinical results. This article summarizes the basic properties of curcumin and its mechanisms of action, with specific emphasis on the etiopathogenesis of depression, preclinical and current clinical evidence, and future research directions, to better understand the possible role of curcumin in treating depression. Curcumin may have antidepressant activities with diverse mechanisms of action involving primarily neurotransmitters, transcription pathways, neurogenesis, the hypothalamic-pituitary-adrenal axis and inflammatory and immune pathways, as demonstrated in various animal and human studies. Current published randomized clinical trials suggest a small, non-significant benefit of curcumin for major depression. More adequately-powered and methodologically improved studies are mandatory.

Original languageEnglish
Pages (from-to)269-280
Number of pages12
JournalExpert Review of Neurotherapeutics
Volume15
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • antidepressant
  • curcumin
  • depression
  • mechanism of action

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Curcumin as a putative antidepressant'. Together they form a unique fingerprint.

  • Cite this

    Seo, H. J., Wang, S. M., Han, C., Lee, S. J., Patkar, A. A., Masand, P. S., & Pae, C. U. (2015). Curcumin as a putative antidepressant. Expert Review of Neurotherapeutics, 15(3), 269-280. https://doi.org/10.1586/14737175.2015.1008457