Curcumin-Eudragit® e PO solid dispersion: A simple and potent method to solve the problems of curcumin

Jinglei Li, Il Woo Lee, Gye Hwa Shin, Xiguang Chen, Hyun Jin Park

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit® E PO polymer. Water solubility of curcumin in curcumin-Eudragit® E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and <sup>1</sup>H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.

Original languageEnglish
Pages (from-to)322-332
Number of pages11
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume94
DOIs
Publication statusPublished - 2015 Jun 22

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Keywords

  • Curcumin
  • Eudragit®l E PO
  • Solid dispersion
  • Stability
  • Transdermal administration
  • Water solubility

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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