Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells

Ji Hae Kim, Ji Man Park, Eung Kyun Kim, Jung Ok Lee, Soo Kyung Lee, Jin Hee Jung, Ga Young You, Sun-Hwa Park, Pann Ghill Shu, Hyeon Soo Kim

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Curcumin has been shown to exert a variety of beneficial human health effects. However, mechanisms by which curcumin acts are poorly understood. In this study, we report that curcumin activated AMP-activated protein kinase (AMPK) and increased glucose uptake in rat L6 myotubes. In addition, curcumin activated the mitogen-activated protein kinase kinase (MEK)3/6-p38 mitogen-activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade. Moreover, inhibition of either AMPK or p38 MAPK resulted in blockage of curcumin-induced glucose uptake. Furthermore, the administration of curcumin to mice increased AMPK phosphorylation in the skeletal muscles. Taken together, these results indicate that the beneficial health effect of curcumin can be explained by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
JournalJournal of Cellular Physiology
Volume223
Issue number3
DOIs
Publication statusPublished - 2010 Jun 1

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AMP-Activated Protein Kinases
Curcumin
Skeletal Muscle Fibers
p38 Mitogen-Activated Protein Kinases
Glucose
Mitogen-Activated Protein Kinase Kinases
Muscle
Skeletal Muscle
MAP Kinase Kinase 3
Health
Phosphorylation
Rats

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells. / Kim, Ji Hae; Park, Ji Man; Kim, Eung Kyun; Lee, Jung Ok; Lee, Soo Kyung; Jung, Jin Hee; You, Ga Young; Park, Sun-Hwa; Shu, Pann Ghill; Kim, Hyeon Soo.

In: Journal of Cellular Physiology, Vol. 223, No. 3, 01.06.2010, p. 771-778.

Research output: Contribution to journalArticle

Kim, JH, Park, JM, Kim, EK, Lee, JO, Lee, SK, Jung, JH, You, GY, Park, S-H, Shu, PG & Kim, HS 2010, 'Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells', Journal of Cellular Physiology, vol. 223, no. 3, pp. 771-778. https://doi.org/10.1002/jcp.22093
Kim, Ji Hae ; Park, Ji Man ; Kim, Eung Kyun ; Lee, Jung Ok ; Lee, Soo Kyung ; Jung, Jin Hee ; You, Ga Young ; Park, Sun-Hwa ; Shu, Pann Ghill ; Kim, Hyeon Soo. / Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells. In: Journal of Cellular Physiology. 2010 ; Vol. 223, No. 3. pp. 771-778.
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