Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells

Moon Sook Woo, Soo Hyun Jung, So Young Kim, Jin Won Hyun, Kwang Ho Ko, Won Ki Kim, Hee Sun Kim

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The aberrant expression of matrix metalloproteinase-9 (MMP-9) is implicated in the invasion and angiogenesis process of brain tumor. This study has investigated the effects of curcumin on MMP-9 expression in human astroglioma cell lines. Curcumin significantly inhibited the MMP-9 enzymatic activity and protein expression that was induced by PMA. The inhibitory effect of curcumin on MMP-9 expression correlates with the decreased MMP-9 mRNA level and the suppression of MMP-9 promoter activity. The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-κB and AP-1 because their DNA binding activities were suppressed by curcumin. Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway. Therefore, the inhibition of MMP-9 expression by curcumin might have therapeutic potential for controlling the growth and invasiveness of brain tumor.

Original languageEnglish
Pages (from-to)1017-1025
Number of pages9
JournalBiochemical and biophysical research communications
Volume335
Issue number4
DOIs
Publication statusPublished - 2005 Oct 7
Externally publishedYes

Keywords

  • AP-1
  • Astroglioma
  • Curcumin
  • Gene expression
  • MAP kinase
  • Matrix metalloproteinase-9
  • NF-κB
  • PKC
  • Signal transduction

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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