TY - JOUR
T1 - Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen
T2 - Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon
AU - Song, Woon Young
AU - Kim, Hak Joong
N1 - Funding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF-2018R1D1A1A02086039) and the Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC), funded by the Korea government (Ministry of Education) (2019R1A6C1010028). Protein images in Fig. 6 were produced with UCSF Chimera, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from NIH P41-GM103311.50
PY - 2020/4
Y1 - 2020/4
N2 - Covering: 1994 to 2019 Owing to the rapid increase in nosocomial infections by antibiotic-resistant Acinetobacter baumannii and the paucity of effective treatment options for such infections, interest in the virulence factors involved in its successful dissemination and propagation in the human host have escalated in recent years. Acinetobacin, a siderophore of A. baumannii, is responsible for iron acquisition under nutritional depravation and has been shown to be one of the key virulence factors for this bacterium. In this Highlight, recent findings regarding various chemical and biological aspects of acinetobactin metabolism closely related to the fitness of A. baumannii at the infection sites have been described. In addition, several notable efforts for identifying novel anti-infectious agents based thereon have been discussed.
AB - Covering: 1994 to 2019 Owing to the rapid increase in nosocomial infections by antibiotic-resistant Acinetobacter baumannii and the paucity of effective treatment options for such infections, interest in the virulence factors involved in its successful dissemination and propagation in the human host have escalated in recent years. Acinetobacin, a siderophore of A. baumannii, is responsible for iron acquisition under nutritional depravation and has been shown to be one of the key virulence factors for this bacterium. In this Highlight, recent findings regarding various chemical and biological aspects of acinetobactin metabolism closely related to the fitness of A. baumannii at the infection sites have been described. In addition, several notable efforts for identifying novel anti-infectious agents based thereon have been discussed.
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U2 - 10.1039/c9np00046a
DO - 10.1039/c9np00046a
M3 - Review article
C2 - 31661538
AN - SCOPUS:85082526437
VL - 37
SP - 477
EP - 487
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 4
ER -