Current concepts of nociception: Nociceptive molecular sensors in sensory neurons

Sun Wook Hwang, Uhtaek Oh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: A large number of channels that are in some way linked to sensory transduction including nociception have been discovered in recent years. This review summarizes newly discovered channels that are implicated in nociception. Furthermore, details are discussed with emphasis on their possible application to clinical use as analgesics. RECENT FINDINGS: Studies with null mutant animals deficient in these channel genes reveal that the channels are indeed implicated in physiological as well as pathological nociception. SUMMARY: Many transient receptor potential channels are thermosensors that detect cold, warm and hot temperatures. These channels are activated not only by natural chemicals such as capsaicin, menthol, and camphor, but by various inflammatory signaling pathways. The acid-sensing ion channel and P2X channel that detect extracellular acidosis and ATP are also implicated in some types of pain. Voltage-gated sodium or calcium channels draw attention because of their involvement in neuropathic pain.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalCurrent Opinion in Anaesthesiology
Volume20
Issue number5
DOIs
Publication statusPublished - 2007 Oct 1

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Keywords

  • ASIC
  • Nav
  • P2X
  • Pain
  • TRP channel

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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