Current hormone therapy associated with atypical squamous cells of undetermined significance in postmenopausal women

Ki Hoon Ahn, Tak Kim, Young Tae Kim, Kyu Wan Lee, Sun Haeng Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: This study evaluated the relationship between hormone therapy (HT) and squamous cytologic abnormalities of the cervix in postmenopausal Korean women. Methods: Two hundred sixty-eight cases of atypical squamous cells of undetermined significance (ASCUS), or more severe cervical lesions, and 4728 negative controls were included in this study. Hormone therapy status was analyzed as functions of 2 categories (current user and noncurrent user) and 3 categories (never user, past user, and current user). Results: With HTusers categorized as current HTusers and noncurrent users, HTuse had a significant relationship with abnormal cervical squamous cells (χ2, P = 0.018). When the noncurrent users were more categorized into never users and past users, the relationship did not exist. There was a greater risk of cellular abnormality among current HT users than never users (odds ratio, 1.805; 95% confidence interval, 1.042-3.127; P = 0.035); the risk was no greater among past users than the never users. The risk was limited to ASCUS and not related to more advanced lesions. Conclusions: In postmenopausal women, current HT use might have an effect on initial abnormal changes of the cervical squamous cells, such as ASCUS; however, the effect is extinguished with respect to more advanced lesions.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalInternational Journal of Gynecological Cancer
Volume19
Issue number4
DOIs
Publication statusPublished - 2009 May 1

Fingerprint

Hormones
Epithelial Cells
Therapeutics
Cervix Uteri
Odds Ratio
Confidence Intervals
Atypical Squamous Cells of the Cervix

Keywords

  • Hormone therapy
  • Liquid-based cytology
  • Postmenopause
  • Uterine cervix

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Current hormone therapy associated with atypical squamous cells of undetermined significance in postmenopausal women. / Ahn, Ki Hoon; Kim, Tak; Kim, Young Tae; Lee, Kyu Wan; Kim, Sun Haeng.

In: International Journal of Gynecological Cancer, Vol. 19, No. 4, 01.05.2009, p. 699-702.

Research output: Contribution to journalArticle

@article{e5daf721916b4bd0a318a5d6da2f0d94,
title = "Current hormone therapy associated with atypical squamous cells of undetermined significance in postmenopausal women",
abstract = "Objective: This study evaluated the relationship between hormone therapy (HT) and squamous cytologic abnormalities of the cervix in postmenopausal Korean women. Methods: Two hundred sixty-eight cases of atypical squamous cells of undetermined significance (ASCUS), or more severe cervical lesions, and 4728 negative controls were included in this study. Hormone therapy status was analyzed as functions of 2 categories (current user and noncurrent user) and 3 categories (never user, past user, and current user). Results: With HTusers categorized as current HTusers and noncurrent users, HTuse had a significant relationship with abnormal cervical squamous cells (χ2, P = 0.018). When the noncurrent users were more categorized into never users and past users, the relationship did not exist. There was a greater risk of cellular abnormality among current HT users than never users (odds ratio, 1.805; 95{\%} confidence interval, 1.042-3.127; P = 0.035); the risk was no greater among past users than the never users. The risk was limited to ASCUS and not related to more advanced lesions. Conclusions: In postmenopausal women, current HT use might have an effect on initial abnormal changes of the cervical squamous cells, such as ASCUS; however, the effect is extinguished with respect to more advanced lesions.",
keywords = "Hormone therapy, Liquid-based cytology, Postmenopause, Uterine cervix",
author = "Ahn, {Ki Hoon} and Tak Kim and Kim, {Young Tae} and Lee, {Kyu Wan} and Kim, {Sun Haeng}",
year = "2009",
month = "5",
day = "1",
doi = "10.1111/IGC.0b013e31819d8b5b",
language = "English",
volume = "19",
pages = "699--702",
journal = "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Current hormone therapy associated with atypical squamous cells of undetermined significance in postmenopausal women

AU - Ahn, Ki Hoon

AU - Kim, Tak

AU - Kim, Young Tae

AU - Lee, Kyu Wan

AU - Kim, Sun Haeng

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Objective: This study evaluated the relationship between hormone therapy (HT) and squamous cytologic abnormalities of the cervix in postmenopausal Korean women. Methods: Two hundred sixty-eight cases of atypical squamous cells of undetermined significance (ASCUS), or more severe cervical lesions, and 4728 negative controls were included in this study. Hormone therapy status was analyzed as functions of 2 categories (current user and noncurrent user) and 3 categories (never user, past user, and current user). Results: With HTusers categorized as current HTusers and noncurrent users, HTuse had a significant relationship with abnormal cervical squamous cells (χ2, P = 0.018). When the noncurrent users were more categorized into never users and past users, the relationship did not exist. There was a greater risk of cellular abnormality among current HT users than never users (odds ratio, 1.805; 95% confidence interval, 1.042-3.127; P = 0.035); the risk was no greater among past users than the never users. The risk was limited to ASCUS and not related to more advanced lesions. Conclusions: In postmenopausal women, current HT use might have an effect on initial abnormal changes of the cervical squamous cells, such as ASCUS; however, the effect is extinguished with respect to more advanced lesions.

AB - Objective: This study evaluated the relationship between hormone therapy (HT) and squamous cytologic abnormalities of the cervix in postmenopausal Korean women. Methods: Two hundred sixty-eight cases of atypical squamous cells of undetermined significance (ASCUS), or more severe cervical lesions, and 4728 negative controls were included in this study. Hormone therapy status was analyzed as functions of 2 categories (current user and noncurrent user) and 3 categories (never user, past user, and current user). Results: With HTusers categorized as current HTusers and noncurrent users, HTuse had a significant relationship with abnormal cervical squamous cells (χ2, P = 0.018). When the noncurrent users were more categorized into never users and past users, the relationship did not exist. There was a greater risk of cellular abnormality among current HT users than never users (odds ratio, 1.805; 95% confidence interval, 1.042-3.127; P = 0.035); the risk was no greater among past users than the never users. The risk was limited to ASCUS and not related to more advanced lesions. Conclusions: In postmenopausal women, current HT use might have an effect on initial abnormal changes of the cervical squamous cells, such as ASCUS; however, the effect is extinguished with respect to more advanced lesions.

KW - Hormone therapy

KW - Liquid-based cytology

KW - Postmenopause

KW - Uterine cervix

UR - http://www.scopus.com/inward/record.url?scp=67651017975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651017975&partnerID=8YFLogxK

U2 - 10.1111/IGC.0b013e31819d8b5b

DO - 10.1111/IGC.0b013e31819d8b5b

M3 - Article

VL - 19

SP - 699

EP - 702

JO - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

SN - 1048-891X

IS - 4

ER -