Current perspective on nasal delivery systems for chronic rhinosinusitis

Junhu Tai, Kijeong Lee, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic rhinosinusitis is an upper respiratory disease during which topical drug treatment via the nasal cavity is the most actively utilized therapeutic strategy. In addition to steroids, antibiotics, and antifungal agents, which are widely used in clinical practice, research on novel topical agents to improve the bacterial biofilm or mucociliary clearance remains ongoing. Moreover, owing to the complex structure of the nasal cavity, the effects of nasal drug delivery vary depending on factors related to delivery fluid dynamics, including device, volume, and compounds. In this article, we review methods and compounds that have been applied to chronic rhinosinusitis management and introduce recent advances and future perspectives in nasal drug delivery for upper respiratory diseases.

Original languageEnglish
Article number246
Pages (from-to)1-21
Number of pages21
JournalPharmaceutics
Volume13
Issue number2
DOIs
Publication statusPublished - 2021 Feb

Keywords

  • Chronic rhinosinusitis
  • Drug delivery
  • Fluid dynamics
  • Topical treatment
  • Upper respiratory diseases

ASJC Scopus subject areas

  • Pharmaceutical Science

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