Current role of selective internal radiation with yttrium-90 in liver tumors

Wan Yee Lau, Yee Leong Teoh, Khin Maung Win, Rheun Chuan Lee, Vanessa H. De Villa, Yun Hwan Kim, Po Chin Liang, Ramon S. Santos-Ocampo, Richard Hoau Gong Lo, Kieron Boon Leng Lim, David Wai Meng Tai, David Chee Eng Ng, Farah Gillan Irani, Apoorva Gogna, Pierce Kah Hoe Chow

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11 Citations (Scopus)


An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.

Original languageEnglish
Pages (from-to)1193-1204
Number of pages12
JournalFuture Oncology
Issue number9
Publication statusPublished - 2016 May 1


  • liver cancer
  • selective internal radiation
  • transarterial chemoembolization
  • yttrium 90 microspheres

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Lau, W. Y., Teoh, Y. L., Win, K. M., Lee, R. C., De Villa, V. H., Kim, Y. H., Liang, P. C., Santos-Ocampo, R. S., Lo, R. H. G., Lim, K. B. L., Tai, D. W. M., Ng, D. C. E., Irani, F. G., Gogna, A., & Chow, P. K. H. (2016). Current role of selective internal radiation with yttrium-90 in liver tumors. Future Oncology, 12(9), 1193-1204.