Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea

Kyung Hee Park, Kyung Hyo Kim, Jin Han Kang, Kwang Nam Kim, Dong Soo Kim, Yun Kyung Kim, Jung Soo Kim, Jong Hyun Kim, Chang Hwi Kim, Hwang Min Kim, Sung Hee Oh, Eun Hee Chung, Sung Ho Cha, Young Youn Choi, Jae Kyun Hur, Young Jin Hong, Su Eun Park, Hoan Jong Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Group B streptococcus (GBS) is the most common cause of invasive neonatal infections in developed countries. The incidence of early-onset GBS disease in Korea is known to be much lower than that in other developed countries; however neonatal GBS disease has been frequently reported in recent years in Korea. This retrospective study sought to determine the current status and clinical presentation of neonatal GBS disease in Korea. Methods: From January 1996 through December 2005, GBS cases (n= 157) diagnosed in blood, cerebrospinal fluid, or other sterile body fluids among infants <3 months of age from 14 university hospitals in Korea were identified. Age of onset, diagnosis, underlying medical conditions, and outcomes were investigated by reviewing the medical records. Results: A total of 157 cases were identified during the study period. Of the cases, 32 were early-onset disease (EOD) and 125 were late-onset disease (LOD). Twenty-six of the EOD cases had symptoms during the first 24 h after birth. One hundred of the 157 GBS cases were diagnosed as meningitis. The mortality rate of EOD was 20.7%. The case fatality rate of LOD was 7.2% and 25.2% of LOD cases had sequelae. Conclusions: GBS is becoming an important cause of invasive neonatal infections in Korea, with LOD being more common. It may not be currently necessary to adopt the prevention guidelines of perinatal GBS disease in Korea. However, studies of maternal GBS carriage rates and neonatal GBS disease will continue.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalPediatrics International
Volume53
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1

Fingerprint

Streptococcal Infections
Streptococcus agalactiae
Korea
Developed Countries
Mortality
Body Fluids
Infection
Age of Onset
Meningitis
Medical Records
Cerebrospinal Fluid
Retrospective Studies
Mothers
Parturition
Guidelines

Keywords

  • epidemiology
  • Group B streptococcus
  • Korea
  • neonate
  • sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea. / Park, Kyung Hee; Kim, Kyung Hyo; Kang, Jin Han; Kim, Kwang Nam; Kim, Dong Soo; Kim, Yun Kyung; Kim, Jung Soo; Kim, Jong Hyun; Kim, Chang Hwi; Kim, Hwang Min; Oh, Sung Hee; Chung, Eun Hee; Cha, Sung Ho; Choi, Young Youn; Hur, Jae Kyun; Hong, Young Jin; Park, Su Eun; Lee, Hoan Jong.

In: Pediatrics International, Vol. 53, No. 2, 01.04.2011, p. 236-239.

Research output: Contribution to journalArticle

Park, KH, Kim, KH, Kang, JH, Kim, KN, Kim, DS, Kim, YK, Kim, JS, Kim, JH, Kim, CH, Kim, HM, Oh, SH, Chung, EH, Cha, SH, Choi, YY, Hur, JK, Hong, YJ, Park, SE & Lee, HJ 2011, 'Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea', Pediatrics International, vol. 53, no. 2, pp. 236-239. https://doi.org/10.1111/j.1442-200X.2010.03165.x
Park, Kyung Hee ; Kim, Kyung Hyo ; Kang, Jin Han ; Kim, Kwang Nam ; Kim, Dong Soo ; Kim, Yun Kyung ; Kim, Jung Soo ; Kim, Jong Hyun ; Kim, Chang Hwi ; Kim, Hwang Min ; Oh, Sung Hee ; Chung, Eun Hee ; Cha, Sung Ho ; Choi, Young Youn ; Hur, Jae Kyun ; Hong, Young Jin ; Park, Su Eun ; Lee, Hoan Jong. / Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea. In: Pediatrics International. 2011 ; Vol. 53, No. 2. pp. 236-239.
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abstract = "Background: Group B streptococcus (GBS) is the most common cause of invasive neonatal infections in developed countries. The incidence of early-onset GBS disease in Korea is known to be much lower than that in other developed countries; however neonatal GBS disease has been frequently reported in recent years in Korea. This retrospective study sought to determine the current status and clinical presentation of neonatal GBS disease in Korea. Methods: From January 1996 through December 2005, GBS cases (n= 157) diagnosed in blood, cerebrospinal fluid, or other sterile body fluids among infants <3 months of age from 14 university hospitals in Korea were identified. Age of onset, diagnosis, underlying medical conditions, and outcomes were investigated by reviewing the medical records. Results: A total of 157 cases were identified during the study period. Of the cases, 32 were early-onset disease (EOD) and 125 were late-onset disease (LOD). Twenty-six of the EOD cases had symptoms during the first 24 h after birth. One hundred of the 157 GBS cases were diagnosed as meningitis. The mortality rate of EOD was 20.7{\%}. The case fatality rate of LOD was 7.2{\%} and 25.2{\%} of LOD cases had sequelae. Conclusions: GBS is becoming an important cause of invasive neonatal infections in Korea, with LOD being more common. It may not be currently necessary to adopt the prevention guidelines of perinatal GBS disease in Korea. However, studies of maternal GBS carriage rates and neonatal GBS disease will continue.",
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AU - Kim, Kyung Hyo

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AU - Kim, Dong Soo

AU - Kim, Yun Kyung

AU - Kim, Jung Soo

AU - Kim, Jong Hyun

AU - Kim, Chang Hwi

AU - Kim, Hwang Min

AU - Oh, Sung Hee

AU - Chung, Eun Hee

AU - Cha, Sung Ho

AU - Choi, Young Youn

AU - Hur, Jae Kyun

AU - Hong, Young Jin

AU - Park, Su Eun

AU - Lee, Hoan Jong

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N2 - Background: Group B streptococcus (GBS) is the most common cause of invasive neonatal infections in developed countries. The incidence of early-onset GBS disease in Korea is known to be much lower than that in other developed countries; however neonatal GBS disease has been frequently reported in recent years in Korea. This retrospective study sought to determine the current status and clinical presentation of neonatal GBS disease in Korea. Methods: From January 1996 through December 2005, GBS cases (n= 157) diagnosed in blood, cerebrospinal fluid, or other sterile body fluids among infants <3 months of age from 14 university hospitals in Korea were identified. Age of onset, diagnosis, underlying medical conditions, and outcomes were investigated by reviewing the medical records. Results: A total of 157 cases were identified during the study period. Of the cases, 32 were early-onset disease (EOD) and 125 were late-onset disease (LOD). Twenty-six of the EOD cases had symptoms during the first 24 h after birth. One hundred of the 157 GBS cases were diagnosed as meningitis. The mortality rate of EOD was 20.7%. The case fatality rate of LOD was 7.2% and 25.2% of LOD cases had sequelae. Conclusions: GBS is becoming an important cause of invasive neonatal infections in Korea, with LOD being more common. It may not be currently necessary to adopt the prevention guidelines of perinatal GBS disease in Korea. However, studies of maternal GBS carriage rates and neonatal GBS disease will continue.

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KW - sepsis

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