Current status and future direction of biodegradable metallic and polymeric vascular scaffolds for next-generation stents

Seung Hyuk Im, Youngmee Jung, Soo Hyun Kim

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Because of the increasing incidence of coronary artery disease, the importance of cardiovascular stents has continuously increased as a treatment of this disease. Biodegradable scaffolds fabricated from polymers and metals have emerged as promising materials for vascular stents because of their biodegradability. Although such stent framework materials have shown good clinical efficacy, it is difficult to decide whether polymers or metals are better vascular scaffolds because their properties are different. Therefore, there are still obstacles in the development of biodegradable vascular scaffolds in terms of improving clinical efficacy. This review analyzes the pros and cons of current stent materials with respect to five key factors for next-generation stent and discusses methods of improvement. Furthermore, we discuss biodegradable electronic stents with electrical conductivity, which has been considered unimportant until now, and highlight electrical conductivity as a key factor in the development of next-generation stents.

Original languageEnglish
Pages (from-to)3-22
Number of pages20
JournalActa Biomaterialia
Volume60
DOIs
Publication statusPublished - 2017 Sep 15

Keywords

  • Biodegradable metallic scaffolds
  • Biodegradable polymeric scaffolds
  • Cardiovascular stents
  • Coronary artery disease
  • Next-generation stents

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering
  • Molecular Biology

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