Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004

Mee Yon Cho, Jin Hee Sohn, Joon Mee Kim, Kyoung Mee Kim, Young Su Park, Woo Ho Kim, Jin Sook Jung, Eun Sun Jung, So Young Jin, Dae Young Kang, Jae Bok Park, Ho Sung Park, You Duck Choi, Sun Hee Sung, Young Bae Kim, Hogeun Kim, Young Kyung Bae, Miseon Kang, Hee Jin Chang, Yang Seok ChaeHee Eun Lee, Do Youn Park, Youn Soo Lee, Yun Kyung Kang, Hye Kyung Kim, Hee Kyung Chang, Soon Won Hong, Young Hee Choi, Okran Shin, Mi Jin Gu, Youn Wha Kim, Gwang Kim, Sei Jin Chang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.

Original languageEnglish
Pages (from-to)853-862
Number of pages10
JournalJournal of Korean Medical Science
Volume25
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

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Gastrointestinal Stromal Tumors
Korea
Mitosis
Survival
Neoplasms
Blood Vessels
Necrosis
Multivariate Analysis
Pathology
Incidence

Keywords

  • Epidemiology
  • Gastrointestinal stromal tumors
  • Pathology
  • Prognosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004. / Cho, Mee Yon; Sohn, Jin Hee; Kim, Joon Mee; Kim, Kyoung Mee; Park, Young Su; Kim, Woo Ho; Jung, Jin Sook; Jung, Eun Sun; Jin, So Young; Kang, Dae Young; Park, Jae Bok; Park, Ho Sung; Choi, You Duck; Sung, Sun Hee; Kim, Young Bae; Kim, Hogeun; Bae, Young Kyung; Kang, Miseon; Chang, Hee Jin; Chae, Yang Seok; Lee, Hee Eun; Park, Do Youn; Lee, Youn Soo; Kang, Yun Kyung; Kim, Hye Kyung; Chang, Hee Kyung; Hong, Soon Won; Choi, Young Hee; Shin, Okran; Gu, Mi Jin; Kim, Youn Wha; Kim, Gwang; Chang, Sei Jin.

In: Journal of Korean Medical Science, Vol. 25, No. 6, 01.06.2010, p. 853-862.

Research output: Contribution to journalArticle

Cho, MY, Sohn, JH, Kim, JM, Kim, KM, Park, YS, Kim, WH, Jung, JS, Jung, ES, Jin, SY, Kang, DY, Park, JB, Park, HS, Choi, YD, Sung, SH, Kim, YB, Kim, H, Bae, YK, Kang, M, Chang, HJ, Chae, YS, Lee, HE, Park, DY, Lee, YS, Kang, YK, Kim, HK, Chang, HK, Hong, SW, Choi, YH, Shin, O, Gu, MJ, Kim, YW, Kim, G & Chang, SJ 2010, 'Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004', Journal of Korean Medical Science, vol. 25, no. 6, pp. 853-862. https://doi.org/10.3346/jkms.2010.25.6.853
Cho, Mee Yon ; Sohn, Jin Hee ; Kim, Joon Mee ; Kim, Kyoung Mee ; Park, Young Su ; Kim, Woo Ho ; Jung, Jin Sook ; Jung, Eun Sun ; Jin, So Young ; Kang, Dae Young ; Park, Jae Bok ; Park, Ho Sung ; Choi, You Duck ; Sung, Sun Hee ; Kim, Young Bae ; Kim, Hogeun ; Bae, Young Kyung ; Kang, Miseon ; Chang, Hee Jin ; Chae, Yang Seok ; Lee, Hee Eun ; Park, Do Youn ; Lee, Youn Soo ; Kang, Yun Kyung ; Kim, Hye Kyung ; Chang, Hee Kyung ; Hong, Soon Won ; Choi, Young Hee ; Shin, Okran ; Gu, Mi Jin ; Kim, Youn Wha ; Kim, Gwang ; Chang, Sei Jin. / Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004. In: Journal of Korean Medical Science. 2010 ; Vol. 25, No. 6. pp. 853-862.
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abstract = "Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1{\%}) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.",
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AU - Park, Young Su

AU - Kim, Woo Ho

AU - Jung, Jin Sook

AU - Jung, Eun Sun

AU - Jin, So Young

AU - Kang, Dae Young

AU - Park, Jae Bok

AU - Park, Ho Sung

AU - Choi, You Duck

AU - Sung, Sun Hee

AU - Kim, Young Bae

AU - Kim, Hogeun

AU - Bae, Young Kyung

AU - Kang, Miseon

AU - Chang, Hee Jin

AU - Chae, Yang Seok

AU - Lee, Hee Eun

AU - Park, Do Youn

AU - Lee, Youn Soo

AU - Kang, Yun Kyung

AU - Kim, Hye Kyung

AU - Chang, Hee Kyung

AU - Hong, Soon Won

AU - Choi, Young Hee

AU - Shin, Okran

AU - Gu, Mi Jin

AU - Kim, Youn Wha

AU - Kim, Gwang

AU - Chang, Sei Jin

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