TY - JOUR
T1 - Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
AU - Kim, Dongkyu
AU - Cho, Gun Sik
AU - Han, Choongseong
AU - Park, Dong Hyuk
AU - Park, Hee Kyung
AU - Woo, Dong Hun
AU - Kim, Jong Hoon
N1 - Funding Information:
This research was supported by the Bio and Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2017M3A9B4042581) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B2001891).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.
AB - Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.
KW - Liver failure
KW - Liver regeneration
KW - Secretome
KW - Stem cell transplantation
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U2 - 10.1007/s13770-017-0093-7
DO - 10.1007/s13770-017-0093-7
M3 - Review article
AN - SCOPUS:85037065222
VL - 14
SP - 653
EP - 665
JO - Tissue Engineering and Regenerative Medicine
JF - Tissue Engineering and Regenerative Medicine
SN - 1738-2696
IS - 6
ER -
