Cushing's syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature.

K. M. Choi, J. H. Seu, Y. H. Kim, E. J. Lee, S. J. Kim, S. H. Baik, D. S. Choi

    Research output: Contribution to journalReview articlepeer-review

    9 Citations (Scopus)

    Abstract

    Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing's syndrome in infants, children and young adults. It is characterized by non-adrenocorticotropic hormone-dependent hypersecretion of cortisol by multiple, pigmented nodules of hyperplastic adrenocortical cells. Biochemically, PPNAD is characterized by elevated levels of plasma and urinary cortisol that are not suppressed by high doses of dexamethasone (8mg/d for 2 days). Pathologically, the adrenal glands contain multiple dark brown or black nodules and the intervening cortical tissue is atrophic. Recognition of this diagnosis, although rare, is important, as bilateral adrenalectomy is the treatment of choice. We experienced a case of Cushing's syndrome due to primary pigmented nodular adrenocortical disease and report it with reviews of the literature.

    Original languageEnglish
    Pages (from-to)68-72
    Number of pages5
    JournalThe Korean journal of internal medicine
    Volume10
    Issue number1
    DOIs
    Publication statusPublished - 1995 Jan

    ASJC Scopus subject areas

    • Internal Medicine

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