Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

Bong Geun Cha, Han Gil Jeong, Dong Wan Kang, Myong Joo Nam, Chi Kyung Kim, Do Yeon Kim, In Young Choi, Seul Ki Ki, Song I. Kim, Ju hee Han, Jaeyun Kim, Seung Hoon Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Intracerebral hemorrhage (ICH), caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles (CeNPs), abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanoparticle-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebrally injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)3582-3592
Number of pages11
JournalNano Research
Volume11
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1

Fingerprint

Cerium compounds
Silicon Dioxide
Lipids
Silica
Nanoparticles
Brain
Magnetic resonance
Macrophages
Scavenging
Imaging techniques
Reactive Oxygen Species
Anti-Inflammatory Agents
Lipid bilayers
Oxygen
Iron oxides
Infiltration
Deterioration
Animals

Keywords

  • ceria nanoparticles
  • imaging
  • intracerebral hemorrhage
  • magnetic mesoporous silica nanoparticle
  • reactive oxygen species
  • therapeutics

ASJC Scopus subject areas

  • Materials Science(all)
  • Electrical and Electronic Engineering

Cite this

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage. / Cha, Bong Geun; Jeong, Han Gil; Kang, Dong Wan; Nam, Myong Joo; Kim, Chi Kyung; Kim, Do Yeon; Choi, In Young; Ki, Seul Ki; Kim, Song I.; Han, Ju hee; Kim, Jaeyun; Lee, Seung Hoon.

In: Nano Research, Vol. 11, No. 7, 01.07.2018, p. 3582-3592.

Research output: Contribution to journalArticle

Cha, BG, Jeong, HG, Kang, DW, Nam, MJ, Kim, CK, Kim, DY, Choi, IY, Ki, SK, Kim, SI, Han, JH, Kim, J & Lee, SH 2018, 'Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage', Nano Research, vol. 11, no. 7, pp. 3582-3592. https://doi.org/10.1007/s12274-017-1924-5
Cha, Bong Geun ; Jeong, Han Gil ; Kang, Dong Wan ; Nam, Myong Joo ; Kim, Chi Kyung ; Kim, Do Yeon ; Choi, In Young ; Ki, Seul Ki ; Kim, Song I. ; Han, Ju hee ; Kim, Jaeyun ; Lee, Seung Hoon. / Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage. In: Nano Research. 2018 ; Vol. 11, No. 7. pp. 3582-3592.
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