Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong, Jong Seung Kim

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Original languageEnglish
Pages (from-to)4702-4705
Number of pages4
JournalOrganic Letters
Volume15
Issue number18
DOIs
Publication statusPublished - 2013 Sep 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Cu<sup>2+</sup>-responsive bimodal (optical/MRI) contrast agent for cellular imaging'. Together they form a unique fingerprint.

  • Cite this