Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong, Jong Seung Kim

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Original languageEnglish
Pages (from-to)4702-4705
Number of pages4
JournalOrganic Letters
Volume15
Issue number18
DOIs
Publication statusPublished - 2013 Sep 20

Fingerprint

Magnetic resonance imaging
Contrast Media
Ions
Imaging techniques
Magnetic resonance
magnetic resonance
optical communication
Copper
ions
Cells
Magnetic Resonance Imaging
copper
Water
probes
cells
water
RAW 264.7 Cells

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging. / Jang, Joo Hee; Bhuniya, Sankarprasad; Kang, Jongeun; Yeom, Areum; Hong, Kwan Soo; Kim, Jong Seung.

In: Organic Letters, Vol. 15, No. 18, 20.09.2013, p. 4702-4705.

Research output: Contribution to journalArticle

Jang, JH, Bhuniya, S, Kang, J, Yeom, A, Hong, KS & Kim, JS 2013, 'Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging', Organic Letters, vol. 15, no. 18, pp. 4702-4705. https://doi.org/10.1021/ol4025293
Jang, Joo Hee ; Bhuniya, Sankarprasad ; Kang, Jongeun ; Yeom, Areum ; Hong, Kwan Soo ; Kim, Jong Seung. / Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging. In: Organic Letters. 2013 ; Vol. 15, No. 18. pp. 4702-4705.
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