Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang; Sankarprasad Bhuniya; Jongeun Kang; Areum Yeom; Kwan Soo Hong; Jong Seung Kim

doi:10.1021/ol4025293

Cu²⁺-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A water-soluble T₁ magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu ²⁺ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Original language	English
Pages (from-to)	4702-4705
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	18
DOIs	https://doi.org/10.1021/ol4025293
Publication status	Published - 2013 Sept 20

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol4025293

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abstract = "A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.",

author = "Jang, {Joo Hee} and Sankarprasad Bhuniya and Jongeun Kang and Areum Yeom and Hong, {Kwan Soo} and Kim, {Jong Seung}",

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AU - Jang, Joo Hee

AU - Bhuniya, Sankarprasad

AU - Kang, Jongeun

AU - Yeom, Areum

AU - Hong, Kwan Soo

AU - Kim, Jong Seung

PY - 2013/9/20

Y1 - 2013/9/20

N2 - A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

AB - A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

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Cu²⁺-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Abstract

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