Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians

Hye-Jin Yoo, Man Sik Park, Chang-Hee Lee, Sae Jeong Yang, Tae Nyun Kim, Kang Il Lim, Hyun Joo Kang, Wook Song, Jong Eun Yeon, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background/aims: Abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Although there have been many studies to determine the optimal cutoff points of waist circumference or visceral fat area in screening for metabolic syndrome, there have been no reports to establish adequate cutoff points of abdominal obesity indices in screening for NAFLD. Therefore, we examined the appropriate cutoff points of abdominal obesity indices associated with NAFLD in Korean men and women using receiver operating characteristic (ROC) curve analysis. Furthermore, we compared the usefulness of various abdominal obesity indices measured using computed tomography (CT), dual-energy X-ray absorptiometry (DXA) and anthropometric parameters for detecting NAFLD. Methods: We analysed the baseline data of an ongoing prospective, observational cohort study, including a total of 456 healthy subjects 20-88 years of age. NAFLD was diagnosed by unenhanced CT using the liver attenuation index. Results: All ROC curves of waist circumference, waist-to-height ratio, DXA-measured trunk fat mass and CT-measured visceral fat area were significantly above the diagonal line. There were no significant differences in the area under the curve values among these abdominal obesity indices in each gender. The appropriate cutoff point of waist circumference in screening for NAFLD was 89 cm for men and 84 cm for women and the optimal cutoff point of waist-to-height ratio was 0.52 for men and 0.53 for women with very high negative predictive values. Conclusions: The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalLiver International
Volume30
Issue number8
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Abdominal Obesity
Waist Circumference
Photon Absorptiometry
Intra-Abdominal Fat
Tomography
ROC Curve
X Ray Computed Tomography
Non-alcoholic Fatty Liver Disease
Area Under Curve
Observational Studies
Healthy Volunteers
Cohort Studies
Fats
Liver
Waist-Height Ratio

Keywords

  • Abdominal obesity
  • Non-alcoholic fatty liver disease
  • Receiver operating characteristic curve analysis
  • Visceral fat
  • Waist circumference

ASJC Scopus subject areas

  • Hepatology

Cite this

Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians. / Yoo, Hye-Jin; Park, Man Sik; Lee, Chang-Hee; Yang, Sae Jeong; Kim, Tae Nyun; Lim, Kang Il; Kang, Hyun Joo; Song, Wook; Yeon, Jong Eun; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Liver International, Vol. 30, No. 8, 01.09.2010, p. 1189-1196.

Research output: Contribution to journalArticle

Yoo, Hye-Jin ; Park, Man Sik ; Lee, Chang-Hee ; Yang, Sae Jeong ; Kim, Tae Nyun ; Lim, Kang Il ; Kang, Hyun Joo ; Song, Wook ; Yeon, Jong Eun ; Baik, Sei-Hyun ; Choi, Dong Seop ; Choi, Kyung Mook. / Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians. In: Liver International. 2010 ; Vol. 30, No. 8. pp. 1189-1196.
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AU - Park, Man Sik

AU - Lee, Chang-Hee

AU - Yang, Sae Jeong

AU - Kim, Tae Nyun

AU - Lim, Kang Il

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Yeon, Jong Eun

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

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N2 - Background/aims: Abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Although there have been many studies to determine the optimal cutoff points of waist circumference or visceral fat area in screening for metabolic syndrome, there have been no reports to establish adequate cutoff points of abdominal obesity indices in screening for NAFLD. Therefore, we examined the appropriate cutoff points of abdominal obesity indices associated with NAFLD in Korean men and women using receiver operating characteristic (ROC) curve analysis. Furthermore, we compared the usefulness of various abdominal obesity indices measured using computed tomography (CT), dual-energy X-ray absorptiometry (DXA) and anthropometric parameters for detecting NAFLD. Methods: We analysed the baseline data of an ongoing prospective, observational cohort study, including a total of 456 healthy subjects 20-88 years of age. NAFLD was diagnosed by unenhanced CT using the liver attenuation index. Results: All ROC curves of waist circumference, waist-to-height ratio, DXA-measured trunk fat mass and CT-measured visceral fat area were significantly above the diagonal line. There were no significant differences in the area under the curve values among these abdominal obesity indices in each gender. The appropriate cutoff point of waist circumference in screening for NAFLD was 89 cm for men and 84 cm for women and the optimal cutoff point of waist-to-height ratio was 0.52 for men and 0.53 for women with very high negative predictive values. Conclusions: The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.

AB - Background/aims: Abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Although there have been many studies to determine the optimal cutoff points of waist circumference or visceral fat area in screening for metabolic syndrome, there have been no reports to establish adequate cutoff points of abdominal obesity indices in screening for NAFLD. Therefore, we examined the appropriate cutoff points of abdominal obesity indices associated with NAFLD in Korean men and women using receiver operating characteristic (ROC) curve analysis. Furthermore, we compared the usefulness of various abdominal obesity indices measured using computed tomography (CT), dual-energy X-ray absorptiometry (DXA) and anthropometric parameters for detecting NAFLD. Methods: We analysed the baseline data of an ongoing prospective, observational cohort study, including a total of 456 healthy subjects 20-88 years of age. NAFLD was diagnosed by unenhanced CT using the liver attenuation index. Results: All ROC curves of waist circumference, waist-to-height ratio, DXA-measured trunk fat mass and CT-measured visceral fat area were significantly above the diagonal line. There were no significant differences in the area under the curve values among these abdominal obesity indices in each gender. The appropriate cutoff point of waist circumference in screening for NAFLD was 89 cm for men and 84 cm for women and the optimal cutoff point of waist-to-height ratio was 0.52 for men and 0.53 for women with very high negative predictive values. Conclusions: The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.

KW - Abdominal obesity

KW - Non-alcoholic fatty liver disease

KW - Receiver operating characteristic curve analysis

KW - Visceral fat

KW - Waist circumference

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