Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells

Claude Carnaud, Daniel Lee, Olivier Donnars, Se-Ho Park, Andrew Beavis, Yasuhiko Koezuka, Albert Bendelac

Research output: Contribution to journalArticle

690 Citations (Scopus)

Abstract

α-Galactosylceramide (α-GalCer) is a glycolipid with potent antitumor properties that binds to CD1d molecules and activates mouse Vα14 and human Vα24 NKT cells. Surprisingly, we found that, as early as 90 min after α- GalCer injection in vivo, NK cells also displayed considerable signs of activation, including IFN-γ production and CD69 induction. NK activation was not observed in RAG- or CD1-deficient mice, and it was decreased by pretreatment with anti-IFN-γ Abs, suggesting that, despite its rapid induction, it was a secondary event that depended on IFN-γ release by NKT cells. At later time points, B cells and CD8 T cells also began to express CD69. These findings identify a high-speed communication network between the innate and adaptive immune systems in vivo that is initiated upon NKT cell activation. They also suggest that the antitumor effects of α-GalCer result from the sequential recruitment of distinct innate and adaptive effector lymphocytes.

Original languageEnglish
Pages (from-to)4647-4650
Number of pages4
JournalJournal of Immunology
Volume163
Issue number9
Publication statusPublished - 1999 Nov 6
Externally publishedYes

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Natural Killer T-Cells
Natural Killer Cells
Immune System
CD1d Antigen
Galactosylceramides
Glycolipids
B-Lymphocytes
Communication
Lymphocytes
T-Lymphocytes
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Carnaud, C., Lee, D., Donnars, O., Park, S-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999). Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. Journal of Immunology, 163(9), 4647-4650.

Cutting edge : Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. / Carnaud, Claude; Lee, Daniel; Donnars, Olivier; Park, Se-Ho; Beavis, Andrew; Koezuka, Yasuhiko; Bendelac, Albert.

In: Journal of Immunology, Vol. 163, No. 9, 06.11.1999, p. 4647-4650.

Research output: Contribution to journalArticle

Carnaud, C, Lee, D, Donnars, O, Park, S-H, Beavis, A, Koezuka, Y & Bendelac, A 1999, 'Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells', Journal of Immunology, vol. 163, no. 9, pp. 4647-4650.
Carnaud, Claude ; Lee, Daniel ; Donnars, Olivier ; Park, Se-Ho ; Beavis, Andrew ; Koezuka, Yasuhiko ; Bendelac, Albert. / Cutting edge : Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. In: Journal of Immunology. 1999 ; Vol. 163, No. 9. pp. 4647-4650.
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