Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells

Claude Carnaud, Daniel Lee, Olivier Donnars, Se-Ho Park, Andrew Beavis, Yasuhiko Koezuka, Albert Bendelac

Research output: Contribution to journalArticle

698 Citations (Scopus)

Abstract

α-Galactosylceramide (α-GalCer) is a glycolipid with potent antitumor properties that binds to CD1d molecules and activates mouse Vα14 and human Vα24 NKT cells. Surprisingly, we found that, as early as 90 min after α- GalCer injection in vivo, NK cells also displayed considerable signs of activation, including IFN-γ production and CD69 induction. NK activation was not observed in RAG- or CD1-deficient mice, and it was decreased by pretreatment with anti-IFN-γ Abs, suggesting that, despite its rapid induction, it was a secondary event that depended on IFN-γ release by NKT cells. At later time points, B cells and CD8 T cells also began to express CD69. These findings identify a high-speed communication network between the innate and adaptive immune systems in vivo that is initiated upon NKT cell activation. They also suggest that the antitumor effects of α-GalCer result from the sequential recruitment of distinct innate and adaptive effector lymphocytes.

Original languageEnglish
Pages (from-to)4647-4650
Number of pages4
JournalJournal of Immunology
Volume163
Issue number9
Publication statusPublished - 1999 Nov 6
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Carnaud, C., Lee, D., Donnars, O., Park, S-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999). Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. Journal of Immunology, 163(9), 4647-4650.