Cyanide as a powerful catalyst for facile preparation of 2-substituted benzoxazoles via aerobic oxidation

Yeon Ho Cho, Chun Young Lee, Deok Chan Ha, Cheol Hong Cheon

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.

Original languageEnglish
Pages (from-to)2992-2996
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume354
Issue number16
DOIs
Publication statusPublished - 2012 Nov 12

Keywords

  • aerobic oxidation
  • benzothiazoles
  • benzoxazoles
  • cyanide
  • one-pot protocol

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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