Cybernetic modeling of the cephalosporin C fermentation process

Research output: Contribution to journalArticle

Abstract

A mathematical model of the cybernetic viewpoints has been developed to describe the production process of cephalosporin C, which is an important natural antibiotic in the pharmaceutical industry. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature. The results obtained show that the model can adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C, so it should be useful to optimize the production process of cephalosporin C by Cephalosporium acremonium in batch or continuous operations.

Original languageEnglish
Pages (from-to)1187-1192
Number of pages6
JournalComputer Aided Chemical Engineering
Volume15
Issue numberC
DOIs
Publication statusPublished - 2003 Dec 1

Fingerprint

Cybernetics
Fermentation
Cells
Antibiotics
Substrates
Drug products
Glucose
Carbon
Mathematical models
Anti-Bacterial Agents
cephalosporin C
Pharmaceutical Preparations
Industry

Keywords

  • cephalosporin C
  • Cephalosporium acremonium
  • cybernetic model
  • diauxic growth
  • morphological differentiation

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Computer Science Applications

Cite this

Cybernetic modeling of the cephalosporin C fermentation process. / Kim, Byung Min; Kim, Seung Wook; Yang, Dae Ryook.

In: Computer Aided Chemical Engineering, Vol. 15, No. C, 01.12.2003, p. 1187-1192.

Research output: Contribution to journalArticle

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