Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalBiotechnology Letters
Volume25
Issue number8
DOIs
Publication statusPublished - 2003 Apr 1

Fingerprint

Cybernetics
Acremonium
Fermentation
Cell Differentiation
Cells
Catabolite Repression
Substrates
Glucose
Theoretical Models
Carbon
Mathematical models
cephalosporin C

Keywords

  • Cephalosporin C
  • Cephalosporium acremonium
  • Cybernetic model
  • Diauxic growth
  • Morphological differentiation

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this

Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium. / Kim, Byung Min; Kim, Seung Wook; Yang, Dae Ryook.

In: Biotechnology Letters, Vol. 25, No. 8, 01.04.2003, p. 611-616.

Research output: Contribution to journalArticle

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