Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

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A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalBiotechnology Letters
Issue number8
Publication statusPublished - 2003 Apr 1



  • Cephalosporin C
  • Cephalosporium acremonium
  • Cybernetic model
  • Diauxic growth
  • Morphological differentiation

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

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