Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Heung Man Lee, Seung Kuk Baek, Soon Young Kwon, Kwang Yoon Jung, Sung Won Chae, Soon Jae Hwang, Jeong Soo Woo, June Young Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume263
Issue number3
DOIs
Publication statusPublished - 2006 Mar

Keywords

  • Cyclooxygenase-1
  • Cyclooxygenase-2
  • Thyroid gland

ASJC Scopus subject areas

  • Otorhinolaryngology

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