Cyclooxygenase 1 and 2 expressions in the human thyroid gland

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5 Citations (Scopus)

Abstract

We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume263
Issue number3
DOIs
Publication statusPublished - 2006 Mar 1

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Cyclooxygenase 1
Cyclooxygenase 2
Thyroid Gland
Adenoma
Carcinoma
Thyroid Neoplasms
Messenger RNA
Carcinoma, Papillary, Follicular
Reverse Transcriptase Polymerase Chain Reaction
Staining and Labeling
Enzymes
Neoplasms

Keywords

  • Cyclooxygenase-1
  • Cyclooxygenase-2
  • Thyroid gland

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "Cyclooxygenase 1 and 2 expressions in the human thyroid gland",
abstract = "We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.",
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T1 - Cyclooxygenase 1 and 2 expressions in the human thyroid gland

AU - Lee, Heung Man

AU - Baek, Seung-Kuk

AU - Kwon, Soon Young

AU - Jung, Kwang-Yoon

AU - Chae, Sungwon

AU - Hwang, Soon Jae

AU - Woo, Jeong-Soo

AU - Lee, Juneyoung

PY - 2006/3/1

Y1 - 2006/3/1

N2 - We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

AB - We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

KW - Cyclooxygenase-1

KW - Cyclooxygenase-2

KW - Thyroid gland

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