CYP2D6 P34S polymorphism and outcomes of escitalopram treatment in Koreans with major depression

Kyu Man Han, Hun Soo Chang, In Kwang Choi, Byung-Joo Ham, Min-Soo Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter individual variation in the efficacy and tolerability of antidepressants in major depressive disorder (MDD). Escitalopram is metabolized by CYP2D6, and recent studies have reported a correlation between clinical outcomes and CYP2D6 genetic polymorphism. The purpose of this study was to determine the relationship between the CYP2D6 P34S polymorphism (C188T, rs1065852) and the efficacy of escitalopram treatment in Korean patients with MDD. Methods A total of 94 patients diagnosed with MDD were recruited for the study and their symptoms were evaluated using the 21-item Hamilton Depression Rating scale (HAMD-21). The association between the CYP2D6 P34S polymorphism and the clinical outcomes (remission and response) was investigated after 1, 2, 4, 8, and 12 weeks of escitalopram treatment using multiple logistic regression analysis and χ2 test. Results The proportion of P allele carriers (PP, PS) in remission status was greater than that of S allele homozygotes (SS) after 8 and 12 weeks of escitalopram treatment. Similarly, P allele carriers exhibited a greater treatment response after 8 and 12 weeks of escitalopram treatment than S allele homozygotes. Conclusion Our results suggest that the P allele of the CYP2D6 P34S polymorphism is a favorable factor in escitalopram treatment for MDD, and that the CYP2D6 P34S polymorphism may be a good genetic marker for predicting escitalopram treatment outcomes.

Original languageEnglish
Pages (from-to)286-293
Number of pages8
JournalPsychiatry Investigation
Volume10
Issue number3
DOIs
Publication statusPublished - 2013 Sep 1

Keywords

  • CYP2D6 polymorphism
  • Escitalopram
  • Major depressive disorder
  • Treatment response

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'CYP2D6 P34S polymorphism and outcomes of escitalopram treatment in Koreans with major depression'. Together they form a unique fingerprint.

  • Cite this