Cysteine-rich 61 (CYR61) inhibits cisplatin-induced apoptosis in ovarian carcinoma cells

Seung Bae Rho, Hyun Jung Byun, Sang Yoon Park, Taehoon Chun

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cysteine-rich 61 (CYR61), a member of the connective tissue factor CCN (Cyr61, CTGF, Nov) family, facilitates angiogenesis by interacting with integrins. Recent observations have indicated that CYR61 also rescues cells from anti-cancer drug-mediated apoptosis but the detailed mechanism underlying the role of CYR61 during apoptosis has not been identified. To better understand the role of CYR61 during cisplatin-induced apoptosis in tumor cells, we overexpressed or inhibited CYR61 expression in human cervical cancer cells (HeLa cells) and measured cisplatin-mediated apoptosis. The results from these experiments clearly demonstrate that CYR61 prevents cisplatin-induced apoptosis by inhibiting caspase-3 activity in HeLa cells. Therefore, CYR61 may be a useful therapeutic target for cisplatin-resistant tumors.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalBiotechnology letters
Volume31
Issue number1
DOIs
Publication statusPublished - 2009 Jan

Keywords

  • Anti-cancer agent
  • Apoptosis
  • Caspase
  • Cisplatin
  • Cysteine-rich 61 (CYR61)
  • Ovarian carcinoma cell

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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