Abstract
Cysteine-rich 61 (CYR61), a member of the connective tissue factor CCN (Cyr61, CTGF, Nov) family, facilitates angiogenesis by interacting with integrins. Recent observations have indicated that CYR61 also rescues cells from anti-cancer drug-mediated apoptosis but the detailed mechanism underlying the role of CYR61 during apoptosis has not been identified. To better understand the role of CYR61 during cisplatin-induced apoptosis in tumor cells, we overexpressed or inhibited CYR61 expression in human cervical cancer cells (HeLa cells) and measured cisplatin-mediated apoptosis. The results from these experiments clearly demonstrate that CYR61 prevents cisplatin-induced apoptosis by inhibiting caspase-3 activity in HeLa cells. Therefore, CYR61 may be a useful therapeutic target for cisplatin-resistant tumors.
Original language | English |
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Pages (from-to) | 23-28 |
Number of pages | 6 |
Journal | Biotechnology letters |
Volume | 31 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 Jan |
Keywords
- Anti-cancer agent
- Apoptosis
- Caspase
- Cisplatin
- Cysteine-rich 61 (CYR61)
- Ovarian carcinoma cell
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology