Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN: In Vitro Tests and First-Principles Calculations

Ke Chen; Nianxiang Qiu; Qihuang Deng; Min Ho Kang; Hui Yang; Jae Uk Baek; Young Hag Koh; Shiyu Du; Qing Huang; Hyoun Ee Kim

doi:10.1021/acsbiomaterials.7b00432

Cytocompatibility of Ti₃AlC₂, Ti₃SiC₂, and Ti₂AlN: In Vitro Tests and First-Principles Calculations

Ke Chen, Nianxiang Qiu, Qihuang Deng, Min Ho Kang, Hui Yang, Jae Uk Baek, Young Hag Koh, Shiyu Du, Qing Huang, Hyoun Ee Kim

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Herein, the cytocompatibility of selected MAX phases, Ti₃AlC₂, Ti₃SiC₂, and Ti₂AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti₂AlN exhibited better cell proliferation and differentiation performance than Ti₃AlC₂ and Ti₃SiC₂. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca²⁺ ions using first-principles calculations. Compared with the partially oxidized TiC_xO_y layer on Ti₃AlC₂ and Ti₃SiC₂, the partially oxidized TiN_xO_y layer on the Ti₂AlN had a stronger affinity to the Ca²⁺ ions, which indicated the good cytocompatibility of Ti₂AlN.

Original language	English
Pages (from-to)	2293-2301
Number of pages	9
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00432
Publication status	Published - 2017 Oct 9

Keywords

MAX phase
TiAlN
cytocompatibility
first-principles calculations
in vitro test

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Access to Document

10.1021/acsbiomaterials.7b00432

Cite this

Cytocompatibility of Ti₃AlC₂, Ti₃SiC₂, and Ti₂AlN : In Vitro Tests and First-Principles Calculations. / Chen, Ke; Qiu, Nianxiang; Deng, Qihuang; Kang, Min Ho; Yang, Hui; Baek, Jae Uk; Koh, Young Hag; Du, Shiyu; Huang, Qing; Kim, Hyoun Ee.

In: ACS Biomaterials Science and Engineering, Vol. 3, No. 10, 09.10.2017, p. 2293-2301.

Research output: Contribution to journal › Article › peer-review

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title = "Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN: In Vitro Tests and First-Principles Calculations",

abstract = "Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.",

keywords = "MAX phase, TiAlN, cytocompatibility, first-principles calculations, in vitro test",

author = "Ke Chen and Nianxiang Qiu and Qihuang Deng and Kang, {Min Ho} and Hui Yang and Baek, {Jae Uk} and Koh, {Young Hag} and Shiyu Du and Qing Huang and Kim, {Hyoun Ee}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China [Grant Nos. 91226202 and 91426304] and CAS Interdisciplinary Innovation Team Project and Ningbo Natural Science Foundation [Grant No. 2016A610273]. K.C. acknowledges financial support received from the China Scholarship Council (CSC) [Grant No. 201608260009]. We thank Dr. Cheol-Min Han from KOREA Institute of Science and Technology for revising our manuscript. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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AU - Qiu, Nianxiang

AU - Deng, Qihuang

AU - Kang, Min Ho

AU - Yang, Hui

AU - Baek, Jae Uk

AU - Koh, Young Hag

AU - Du, Shiyu

AU - Huang, Qing

AU - Kim, Hyoun Ee

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China [Grant Nos. 91226202 and 91426304] and CAS Interdisciplinary Innovation Team Project and Ningbo Natural Science Foundation [Grant No. 2016A610273]. K.C. acknowledges financial support received from the China Scholarship Council (CSC) [Grant No. 201608260009]. We thank Dr. Cheol-Min Han from KOREA Institute of Science and Technology for revising our manuscript. Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/10/9

Y1 - 2017/10/9

N2 - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.

AB - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.

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