TY - JOUR
T1 - Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN
T2 - In Vitro Tests and First-Principles Calculations
AU - Chen, Ke
AU - Qiu, Nianxiang
AU - Deng, Qihuang
AU - Kang, Min Ho
AU - Yang, Hui
AU - Baek, Jae Uk
AU - Koh, Young Hag
AU - Du, Shiyu
AU - Huang, Qing
AU - Kim, Hyoun Ee
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China [Grant Nos. 91226202 and 91426304] and CAS Interdisciplinary Innovation Team Project and Ningbo Natural Science Foundation [Grant No. 2016A610273]. K.C. acknowledges financial support received from the China Scholarship Council (CSC) [Grant No. 201608260009]. We thank Dr. Cheol-Min Han from KOREA Institute of Science and Technology for revising our manuscript.
PY - 2017/10/9
Y1 - 2017/10/9
N2 - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.
AB - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.
KW - MAX phase
KW - TiAlN
KW - cytocompatibility
KW - first-principles calculations
KW - in vitro test
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U2 - 10.1021/acsbiomaterials.7b00432
DO - 10.1021/acsbiomaterials.7b00432
M3 - Article
AN - SCOPUS:85030787555
VL - 3
SP - 2293
EP - 2301
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 10
ER -