Abstract
Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.
| Original language | English |
|---|---|
| Pages (from-to) | 2293-2301 |
| Number of pages | 9 |
| Journal | ACS Biomaterials Science and Engineering |
| Volume | 3 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2017 Oct 9 |
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Keywords
- cytocompatibility
- first-principles calculations
- in vitro test
- MAX phase
- TiAlN
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
Cite this
Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN : In Vitro Tests and First-Principles Calculations. / Chen, Ke; Qiu, Nianxiang; Deng, Qihuang; Kang, Min Ho; Yang, Hui; Baek, Jae Uk; Koh, Young-Hag; Du, Shiyu; Huang, Qing; Kim, Hyoun Ee.
In: ACS Biomaterials Science and Engineering, Vol. 3, No. 10, 09.10.2017, p. 2293-2301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN
T2 - In Vitro Tests and First-Principles Calculations
AU - Chen, Ke
AU - Qiu, Nianxiang
AU - Deng, Qihuang
AU - Kang, Min Ho
AU - Yang, Hui
AU - Baek, Jae Uk
AU - Koh, Young-Hag
AU - Du, Shiyu
AU - Huang, Qing
AU - Kim, Hyoun Ee
PY - 2017/10/9
Y1 - 2017/10/9
N2 - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.
AB - Herein, the cytocompatibility of selected MAX phases, Ti3AlC2, Ti3SiC2, and Ti2AlN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti2AlN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiCxOy layer on Ti3AlC2 and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti2AlN had a stronger affinity to the Ca2+ ions, which indicated the good cytocompatibility of Ti2AlN.
KW - cytocompatibility
KW - first-principles calculations
KW - in vitro test
KW - MAX phase
KW - TiAlN
UR - http://www.scopus.com/inward/record.url?scp=85030787555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030787555&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.7b00432
DO - 10.1021/acsbiomaterials.7b00432
M3 - Article
VL - 3
SP - 2293
EP - 2301
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 10
ER -