Cytogenetic and comparative genomic hybridization studies of an esophageal giant fibrovascular polyp: A case report

Zhongxin Yu, Barbara L. Bane, Ji-Yun Lee, Jan V. Pitha, Marvin Peyton, John Houck, Shibo Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Esophageal giant fibrovascular polyps are rare and are thought to represent redundant tumorlike or hamartomatous esophageal folds. Although most patients present with slowly evolving dysphagia, a minority present with acute respiratory distress or even death caused by asphyxia. We present the pathologic and cytogenetic findings of an 18-cm esophageal giant fibrovascular polyp in a 49-year-old woman who presented with odynophagia and dysphagia. The histologic findings are that of classic esophageal giant fibrovascular polyp as previously described in the literature. Cytogenetic study revealed an abnormal karyotype, and comparative genomic hybridization analysis showed regional amplifications of chromosomes 3 and 12 and a possible loss of 22q13.3-qter. The significance of these cytogenetic findings is unclear but may suggest a neoplastic process in the pathogenesis of esophageal giant fibrovascular polyps.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalHuman Pathology
Volume43
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1
Externally publishedYes

Keywords

  • Comparative genomic hybridization
  • Esophageal giant fibrovascular polyp
  • Ring chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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